Portal da USP Portal da USP Portal da USP

Antibacterial efficacy of intracanal medicaments on bacterial biofilm: a critical review

Carlos Estrela, Gilson Blitzkow Sydney, José Antonio Poli Figueiredo, Cyntia Rodrigues de Araújo Estrela


The purpose of this paper is to discuss critically the antibacterial efficacy of intracanal medicaments on bacterial biofilm. Longitudinal studies were evaluated by a systematic review of English-language articles retrieved from electronic biomedical journal databases (MEDLINE, EMBASE, CENTRAL) and handsearching records, using different matches of keywords for root canal biofilm, between 1966 and August 1st, 2007. The selected articles were identified from titles, abstracts and full-text articles by two independent reviewers, considering the tabulated inclusion and exclusion criteria. Disagreements were resolved by consensus. The search retrieved 91 related articles, of which 8.8% referred to in vivo studies demonstrating the lack of efficacy of endodontic therapy on bacterial biofilm. Intracanal medicaments were found to have a limited action against bacterial biofilm.


Biofilm;Intracanal medicaments;Antimicrobial efficacy

Full Text:


DOI: http://dx.doi.org/10.1590/S1678-77572009000100002

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


  • There are currently no refbacks.