Prevention of amphotericin B nephrotoxicity through use of phytotherapeutic medication
AbstractObjective To evaluate the effect of diosmin and hesperidin flavonoids in the prevention of amphotericin B nephrotoxicity, through an experimental model on rats. Method Adult, male Wistar rats were distributed into the following groups: saline; diosmin hesperidin (animals that received 50 mg/kg of diosmin hesperidin, drinking water, for ten days); amphotericin B (animals that received 15 mg/kg/day of amphotericin B through intraperitoneal treatment for five days); amphotericin B+diosmin hesperidin. Renal function, fractional excretion of sodium; potassium and magnesium and oxidative metabolites were evaluated. Results Treatment with amphotericin B reduced renal function, as shown by the clearance of creatinine, increased tubular function markers and fractional excretion of sodium, potassium, magnesium and oxidative metabolites. Pre-treatment with diosmin hesperidin ameliorated clearance of creatinine and reduced tubular and oxidative injury. Conclusion Administration of amphotericin B resulted in reduction of renal function with tubular injury, and diosmin hesperidin showing an antioxidant protective effect on the kidneys.
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Schlottfeldt, F. dos S., Fernandes, S. M., Martins, D. M., Cordeiro, P., Fonseca, C. D. da, Watanabe, M., & Vattimo, M. de F. F. (2015). Prevention of amphotericin B nephrotoxicity through use of phytotherapeutic medication . Revista Da Escola De Enfermagem Da USP, 49(spe), 74-79. https://doi.org/10.1590/S0080-623420150000700011