Postoperative evolution of insulin sensitivity in diabetic patients

leeve gastrectomy vs Roux-en-Y gastric bypass


The purpose of this study was to compare postoperative evolution of insulin sensibility in diabetic patients after the two most relevant bariatric surgeries nowadays, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). A retrospective cohort study was conducted with type 2 diabetic patients, who underwent RYGB or SG from 2013 to 2018. The laboratory and anthropometric data was analyzed pre-surgery and during a 2-year follow-up. The tool chosen for this comparison was the HOMA2 nonlinear equations, calculated from fasting glycemia and blood insulin. The two surgical procedures were compared. There was significant difference between both evolutions in the first 6-months follow-up (p=0.029), but no difference was presented at the 1-year (p=0.053) or at the 2-year follow-up (p>0.05). Therefore, there was no long-term difference between surgeries, which fuels discussions about their mechanisms of action and their relevance in the treatment of insulin resistance.


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D’Elia, R., Cleva, R., Camarotto, F., Barreto, M., Ferradans, I., Chagas, K. J., & Santo, M. A. (2019). Postoperative evolution of insulin sensitivity in diabetic patients. Revista De Medicina, 98(Suppl), 3-3.