Células-tronco mesenquimais

uma nova perspectiva no tratamento da pneumonia induzida pelo SARS-Cov-2 (COVID-19)

Palavras-chave: Infecções por coronavírus, Coronavírus, Células-tronco mesenquimais, Pneumonia, Doenças respiratórias

Resumo

A biologia das células-tronco é um dos campos mais dinâmicos e promissores das ciências biológicas, pois é a base do desenvolvimento dos organismos. Sua complexidade biológica vem demandando esforços de diversas linhas de pesquisa visando principalmente sua utilização terapêutica. As células-tronco mesenquimais (CTMs), após sua infusão no organismo receptor, tendem a se acumular no pulmão melhorando o microambiente, protegendo as células epiteliais dos alvéolos e prevenindo a formação de fibrose de forma a restaurar a função dos pulmões. Por meio dos processos seguros e eficazes de supressão dos processos inflamatórios e reparação do tecido pulmonar, as CTMs surgem como uma promissora abordagem terapêutica para o tratamento de doenças respiratórias. Neste trabalho abordamos o estado da arte e o potencial terapêutico das CTMs no tratamento de pacientes acometidos por pneumonia em decorrência da COVID-19.

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Biografia do Autor

Enrico Jardim Clemente Santos, CELLTROVET

Instituição na qual o trabalho foi realizado: CELLTROVET e Hospital Israelita Albert Einstein.
CELLTROVET, São Paulo, SP.

Oskar Grau Kaufmann, Hospital Israelita Albert Einstein

Hospital Israelita Albert Einstein, São Paulo, SP. 

Angela Mazzeo, Universidade de São Paulo

Universidade de São Paulo, São Paulo, SP.

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Publicado
2020-06-15
Como Citar
Santos, E., Kaufmann, O., & Mazzeo, A. (2020). Células-tronco mesenquimais. Revista De Medicina, 99(3), 272-277. https://doi.org/10.11606/issn.1679-9836.v99i3p272-277
Seção
Artigos de Revisão/Review Articles