O lado saudável do consumo de bebida alcoólica

Autores

  • Bianca de Almeida-Pititto Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição
  • Ana Carolina Franco de Moraes Faculdades Metropolitanas Unidas
  • Sandra Roberta G. Ferreira Universidade de São Paulo. Faculdade de Saúde Pública

DOI:

https://doi.org/10.11606/issn.2316-9036.v0i96p55-68

Palavras-chave:

consumo de álcool, saúde.

Resumo

Abordam-se evidências da associaçãodo consumo de bebidas alcoólicas com benefícios à saúde, segundo diferenças na sua composição. Efeitos benéficosdo consumo moderado na redução dorisco de doenças cardiovasculares e câncer relacionam-se ao teor de etanol e compostos polifenólicos. Estes têm sido atribuídos a propriedades antioxidantes,anti-inflamatórias, ação sobre as concentraçõesde lipoproteínas e expressão de moléculas de adesão, melhorando a sensibilidade à insulina e a função endotelial.O resveratrol, polifenol presente especialmente no vinho tinto, reduz o riscode certos cânceres também devido a ações antimutagênica, antimetastática, antiproliferativae proapoptótica; porém, aind anão há recomendação para o consumode bebida alcoólica com vistas a tal efeito.

Downloads

Os dados de download ainda não estão disponíveis.

Biografia do Autor

  • Bianca de Almeida-Pititto, Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição

    é médica, pesquisadora de pós-doutorado na Faculdade de Saúde Pública da USP e coorientadora de doutorado no Departamento de Nutrição da FSP-USP.

  • Ana Carolina Franco de Moraes, Faculdades Metropolitanas Unidas

    Nutricionista,doutoranda do Programa de Pós-graduação em Nutrição em Saúde Pública da Faculdade de Saúde Pública da Universidade de São Paulo e professora do curso de Nutrição das Faculdades Metropolitanas Unidas.

  • Sandra Roberta G. Ferreira, Universidade de São Paulo. Faculdade de Saúde Pública

    Médica endocrinologista e professora titular do Departamento de Nutrição da Faculdade de Saúde Pública da Universidade de São Paulo. 

Referências

ALLEN, N. E. et al. “Million Women Study Collaborators: Moderate Alcohol Intake and Cancer Incidence in Women”, in J Natl Cancer Inst, 101, 2009, pp. 296–305.

ANDRADE, A. G. D.; OLIVEIRA, L. C. “Principais Consequências em Longo Prazo Relacionadas ao Consumo Moderado de Álcool”, in A. G. Andrade; J. C. Anthony; C. M. Silveira. Álcool e suas Consequências, uma Abordagem Multiconceitual. Barueri, Manole, 2009, pp. 37-66.

ANGELASKIS, E.; ARMOUGOM, F.; MILLION, M.; RAOULT, D. “The Relationship Between Gut Microbiota and Weight Gain in Humans”, in Future Microbiol, 7(1), 2012, pp. 91-109.

ARRANZ, S.; CHIVA-BLANCH, G.; VALDERAS-MARTÍNEZ, P.; MEDINA-REMÓN, A.; LAMUELA-RAVENTÓS, R. M.; ESTRUCH, R. “Wine, Beer, Alcohol and Polyphenols on Cardiovascular Disease and Cancer”, in Nutrients, 4, 2012, pp. 759-81.

BEULENS, J. W.; RIMM, E. B.; ASCHERIO, A.; SPIEGELMAN, D.; HENDRIKS, H. F. J.; MUKAMAL, K. J. “Alcohol Consumption and Risk for Coronary Heart Disease Among Men with Hypertension”, in Ann. Intern. Med., 146(1), 2007, pp. 10-9.

BHATT, S. R.; LOKHANDWALA, M. F.; BANDAY, A. A. “Resveratrol Prevents Endothelial Nitric Oxide Synthase Uncoupling and Attenuates Development of Hypertension in Spontaneously Hypertensive Rats”, in Eur. J. Pharmacol, 667, 2011, pp. 258-64.

BIANCHINI, F.; VAINIO, H. “Wine and Resveratrol: Mechanisms of Cancer Prevention?”, in Eur. J. Cancer Prev., 12, 2003, pp. 417-25.

BÖHM, M.; ROSENKRANZ, S.; LAUFS, U. “Alcohol and Red Wine: Impact on Cardiovascular Risk”, in Nephrol. Dial. Transplant, 19(1), 2004, pp. 11-6.

CALLACI, J. J.; JUKNELIS, D.; PATWARDHAN, A.; SARTORI, M.; FROST, N.; WEZEMAN, F. H. “The Effects of Binge Alcohol Exposure on Bone Resorption and Biomechanical and Structural Properties Are Offset by Concurrent Bisphosphonate Treatment”, in Alcohol Clin. Exp. Res., 28, 2004, pp. 182-91.

CAMARGO JR., C. A. et al. “Prospective Study of Moderate Alcohol Consumption and Risk of Peripheral Arterial Disease in US Male Physicians”, in Circulation, 95, 1997, pp. 577-80.

CARICILLI, A. M. et al. “Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice”, in Biol., 9(12), 2011. Disponível em: www.e1001212.doi:10.1371/journal.pbio.1001212.

CHIVA-BLANCH, G. et al. “Differential Effects of Polyphenols and Alcohol of Red Wine on the Expression of Adhesion Molecules and Inflammatory Cytokines Related to Atherosclerosis : a Randomized Clinical Trial”, in Am. J. Clin. Nutr., 95, 2012, pp. 326-34.

CRESCENTE, M.; JESSEN, G.; MOMI, S.; HOLTJE, H. D.; GRESELE, P.; CERLETTI, C.; GAETANO, G. “Interactions of Gallic Acid, Resveratrol, Quercetin and Aspirin at the Platelet Cyclooxygenase-1level. Functional and Modelling Studies”, in Thromb.,

, 2009, pp. 336-46.

DELZENNE, N. M.; NEYRINCK, A. M.; CANI, P. D. “Modulation of the Gut Microbiota by Nutrients with Prebiotic Properties: Consequences for Host Health in the Context of Obesity and Metabolic Syndrome”, in Microb Cell Fact., 10(Suppl 1), 2011, S10.

DJOUSSÉ, L.; LEVY, D.; MURABITO, J. M.; CUPPLES, L. A.; ELISSON, R. C. “Alcohol Consumption and Risk of Intermittent Claudication in the Framingham Heart Study”, in Circulation, 102, 2000, p. 3.092.

FAN, E.; ZHANG, L.; JIANG, S.; BAI, Y. “Beneficial Effects of Resveratrol on Atherosclerosis”, in J. Med. Food, 11(4), 2008, pp. 610-4.

FERNÁNDEZ-MAR, M. I.; MATEOS, R.; GARCÍA-PARRILLA, M. C.; PUERTAS, B.; CANTOS-VILLAR, E. “Bioactive Compounds in Wine: Resveratrol, Hydroxytyrosol and Melatonin: A Review”, in Food Chemistry, 130(4), 2012, pp. 797-813.

FERRÁNDEZ, H. S. O.; CONDE, J. J.; SÁNCHEZ-FONT, A.; MARRUGAT, J. Cardiovascular Risk Profile and Type of Alcohol Beverage Consumption: A Population-Based Study”, in Ann. Nutr. Metab., 49, 2005, pp. 100-6.

FERRIÈRES, J. “The French Paradox: Lessons for Other Countries”, in Heart, 90, 2004, pp. 107-11.

FRIEDMAN, L. A.; KIMBALL, A. W. “Coronary Heart Disease Mortality and Alcohol Consumption in Framingham”, in Am. J. Epidemiol., 124(3), 1986, pp. 481-9.

FUCHS, C. S. et al. “Alcohol Consumption and Mortality Among Women”, in N. Engl. J. Med., 332, 1995, p. 1.245.

FUCHS, F. D. et al. “Alcohol Consumption and the Incidence of Hypertension: the Atherosclerosis Risk in Communities Study”, in Hypertension, 37, 2001, p. 1.242.

GERHAUSER, C. et al. “Cancer Chemopreventive Activity of Xanthohumol, a Natural Product Derived from Hop”, in Mol. Cancer Ther., 1(11), 2002, pp. 959-69.

GRONBAEK, M.; BECKER, U.; JOHANSEN, D.; GOTTSCHAU, A.; SCHNOHR, P.; HEIN, H. O.; JENSEN, G.; SØRENSEN, T. I. A. “Type of Alcohol Consumed and Mortality from All Causes, Coronary Heart Disease, and Cancer”, in Ann. Intern. Med., 133(6), 2000, pp. 411-9.

GRONBAEK, M. N.; SØRENSEN, T. I.; JOHANSEN, D.; BECKER, U.; GOTTSCHAU, A.; SCHNOHR, P.; HEIN, H. O.; JENSEN, G. “Beer, Wine, Spirits and Mortality”, in Lakartidningen, 98, 2000, pp. 2.585–88.

HARRIS, K.; KASSIS, A.; MAJOR, G.; CHOU, C. J. “Is the Gut Microbiota a New Factor Contributing to Obesity and Its Metabolic Disorders?”, in J. Obes., [Internet]. 2012; ID: 879151. Disponível em: http://www.pubmedcentral.nih.gov/articlerender.fcgi?a

rtid=3270440&tool=pmcentrez&rendertype=abstract.

HVIDTFELDT, U. A. et al. “Alcohol Intake and Risk of Coronary Heart Disease in Younger, Middle-aged, and Older Adults”, in Circulation, 121(14), 2010, pp. 1.589-97.

JAPUNDZIC, D.; METELKO, Z.; POZGAJ F. “Cardiovascular Benefits and Risks of Moderate Alcohol Consumption in Diabetes Mellitus”, in Diabetologia Croatica, 32(4), 2003, pp. 151–6.

JIMENEZ, M. et al. “Alcohol Consumption and Risk of Stroke in Women”, in Stroke, 43, 2012, pp. 939-45.

KERR-CORRÊA, F. et al. “Differences in Patterns of Alcohol Use Between Men and Women in Botucatu, São Paulo”, in I. Obot; R. Room. Alcohol, Gender and Drinking Problems, a Perspective from Low and Middle Income Countries. Genebra, World

Health Organization, 2005, pp. 49-68.

LASSALETTA, A. D. et al. “Cardioprotective Effects of Red Wine and Vodka in a Model of Endothelial Dysfunction”, in The Journal of Surgical Research 2012, pp. 1-7. Disponível em: http://www.ncbi.nlm.nih.gov/pubmed/22748601.

LASSALETTA, A. D. et al. “Cardioprotective Effects of Red Wine and Vodka in a Model of Endothelial Dysfunction”, in JSR [Internet], 2012/Jun/21 [cited 2012 Oct 8], pp. 1-7. Disponível em: http://www.ncbi.nlm.nih.gov/pubmed/22748601.

LEIHERER, A.; MÜNDLEIN, A.; DREXEL. H. “Phytochemicals and Their Impact on Adipose Tissue Inflammation and Diabetes”, in Vascular Pharm. Sep., 2012. Disponível em: http://www.ncbi.nlm.nih.gov/pubmed/22982056.

MALINSKI, M. K. et al. “Alcohol Consumption and Cardiovascular Disease Mortality in Hypertensive Men”, in Arch. Intern. Med., 2004; 164:623.

MARQUES-VIDAL, P. et al. “Different Alcohol Drinking and Blood Pressure Relationships in France and Northern Ireland. The PRIME Study”, in Hypertension, 38, 2001, pp. 1.361-6.

MATOS, R. S.; et al. “Resveratrol Provoca Efeitos Antiaterogênicos em um Modelo Animal de Aterosclerose”, in Arq. Bras. Cardiol., 98(2), 2012, pp. 136-42.

McCARTY, C. A. et al. “Alcohol, Genetics and Risk of Breast Cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial”, in Breast Cancer Res. Treat., 133, 2012, pp. 785-92.

MUKAMAL, K. J. et al. “Alcohol and Risk for Ischemic Stroke in Men: the Role of Drinking Patterns and Usual Beverage”, in Ann. Intern. Med., 142, 2005, p. 11.

MUKAMAL, K. J.; CHEN, C. M.; RAO, S. R.; BRESLOW, R. A. “Alcohol Consumption and Cardiovascular Mortality Among U.S. Adults, 1987 to 2002”, in J. Am. Coll. Cardiol., 55, 2010, p. 1.328.

NAIMI, T. S. et al. “Cardiovascular Risk Factors and Confounders Among Nondrinking and Moderate-Drinking U.S. Adults”, in Am. J. Prev. Med., 28, 2005, p. 369.

NOVA, E.; BACCAN, G. C.; VESES, A.; ZAPATERA, B.; MARCOS, A. “Potential Health Benefits of Moderate Alcohol Consumption: Current Perspectives in Research”, in The Proceedings of the Nutrition Society, 71(2), 2012, pp. 307–15.

PAI, J. K.; MUKAMAL, K. J.; RIMM, E. B. “Long-term Alcohol Consumption in Relation to All-cause and Cardiovascular Mortality Among Survivors of Myocardial Infarction: the Health Professionals Follow-up Study”, in Eur. Heart. J., 33, 2012, pp. 1.598–605.

PALMIERI, D. et al. “Resveratrol Counteracts Systemic and Local Inflammation Involved in Early Abdominal Aortic Aneurysm Development”, in J. Surg. Res., 171, 2011, pp. e237–e246.

PERIS-BONDIA, F.; LATORRE, A.; ARTACHO, A.; MOYA, A.; D’AURIA, G. “The Active Human Gut Microbiota Differs from the Total Microbiota”, in PLoS ONE., 6(7), 2011, pp. e22448.

QUEIPO-ORTUÑO, M. I. et al. “Influence of Red Wine Polyphenols and Ethanol on the Gut Microbiota”, in Am. J. Clin. Nutr., 95, 2012, pp. 1.323–34.

RAMÓN, R.; MIRANDA, A.; VERGARA, L. “Modulation of Endogenous Antioxidant System by Wine Polyphenols in Human Disease”, in Clinica Chimica Acta, 412, 2011, pp. 410–24.

RAMOS, S. “Cancer Chemoprevention and Chemotherapy: Dietary Polyphenols and Signaling Pathways”, in Mol. Nutr. Food. Res., 52, 2008, pp. 507–26.

RENAUD, S.; DE LORGERIL, M. “Wine, Alcohol, Platelets, and the French Paradox for Coronary Heart Disease”, in Lancet, 339, 1992, pp. 1.523–6.

RENAUD, S.; LANZMANN-PETITHORY, D.; GUEGUEN, R.; CONARD, P. “Alcohol and Mortality from All Causes”, in Biol. Res., 37, 2004, pp. 183–7.

SACANELLA, E. et al. “Down-regulation of Adhesion Molecules and Other Inflammatory Biomarkers After Moderate Wine Consumption in Healthy Women: a Randomized Trial”, in Am. J. Clin. Nutr., 86(5), 2007, pp. 1.463–9.

SEITZ, H. K.; PELUCCHI, C.; BAGNARDI, V.; LA VECCHIA, C. “Epidemiology and Pathophysiology of Alcohol and Breast Cancer: Update 2012”, in Alcohol, 47, 2012, pp. 204–12.

SIQUEIRA, P. B.; BOLINI, H. M. A.; MACEDO, G. A. “O Processo de Fabricação da Cerveja e Seus Efeitos na Presença de Polifenóis”, in Alim. Nutr., 19(4), 2008, pp. 491–8.

SUNG, K-C.; KIM, S. H.; REAVEN, G. M. “Relationship Among Alcohol, Body Weight, and Cardiovascular Risk Factors in 27,030 Korean Men”, in Diabetes Care, 30, 2007, pp. 2.690-94.

THUN, M. J. et al. “Alcohol Consumption and Mortality Among Middle-aged and Elderly U.S. Adults”, in N. Engl. J. Med., 337(24), 1997, pp. 1.705-14.

USA – United States of America. Department of Agriculture Food and Nutrition Information Center. Dietary Guidelines for Americans. Report of the Dietary Advisory Committee on the Dietary Guidelines for Americans, 2000.

VINSON, J. A.; MANDARANO, M.; HIRST, M.; TREVITHICK, J. R.; BOSE, P. “Phenol Antioxidant Quantity and Quality in Foods: Beers and the Effect of Two Types of Beer on an Animal Model of Atherosclerosis”, in J. Agric. Food. Chem., 51, 2003, pp.

528-33.

WHO – World Health Organization, International Agency for Research on Cancer – IARC. “Monographs on the Evaluation of Carcinogenic Risks to Humans: Alcohol Consumption and Ethyl Carbamate. France, IARC, 2010, vol. 6.

WHO – World Health Organization. International Guide for Monitoring Alcohol Consumption and Related Harm. Geneva, WHO, 2000.

WHO – World Health Organization. Alcohol, Gender and Drinking Problems. Edited by Isidore S. Obot & Robin Room. Geneva, Department of Mental Health and Substance Abuse, 2005.

YUSUF, S.; HAWKEN, S.; OUNPUU, S.; DANS, T.; AVEZUM, A.; LANAS, F. et al. “Effect of Potentially Modifiable Risk Factors Associated with Myocardial Infarction in 52 Countries (the INTERHEART study): Case-control Study”, in Lancet, 364, 2004, pp. 937-52.

Downloads

Publicado

2013-02-28

Edição

Seção

Dossiê

Como Citar