LEPROSY NEPHROPATHY: A REVIEW OF CLINICAL AND HISTOPATHOLOGICAL FEATURES

Authors

  • Geraldo Bezerra da Silva Junior University of Fortaleza; Health Sciences Center; School of Medicine; Master in Collective Health
  • Elizabeth De Francesco Daher Federal University of Ceará; Department of Internal Medicine; Post-Graduation Program in Medical Sciences
  • Roberto da Justa Pires NETO Federal University of Ceará; School of Medicine; Department of Community Health
  • Eanes Delgado Barros Pereira Federal University of Ceará; Department of Internal Medicine; Post-Graduation Program in Medical Sciences
  • Gdayllon Cavalcante Meneses Federal University of Ceará; School of Pharmacy
  • Sônia Maria Holanda Almeida Araújo University of Fortaleza; Health Sciences Center; School of Medicine; Master in Collective Health
  • Elvino José Guardão Barros Federal University of Rio Grande do Sul; School of Medicine; Department of Internal Medicine

Abstract

Leprosy is a chronic disease caused by Mycobacterium leprae, highly incapacitating, and with systemic involvement in some cases. Renal involvement has been reported in all forms of the disease, and it is more frequent in multibacillary forms. The clinical presentation is variable and is determined by the host immunologic system reaction to the bacilli. During the course of the disease there are the so called reactional states, in which the immune system reacts against the bacilli, exacerbating the clinical manifestations. Different renal lesions have been described in leprosy, including acute and chronic glomerulonephritis, interstitial nephritis, secondary amyloidosis and pyelonephritis. The exact mechanism that leads to glomerulonephritis in leprosy is not completely understood. Leprosy treatment includes rifampicin, dapsone and clofazimine. Prednisone and non-steroidal anti-inflammatory drugs may be used to control acute immunological episodes.

Downloads

Download data is not yet available.

Downloads

Published

2015-02-01

Issue

Section

Review

How to Cite

LEPROSY NEPHROPATHY: A REVIEW OF CLINICAL AND HISTOPATHOLOGICAL FEATURES . (2015). Revista Do Instituto De Medicina Tropical De São Paulo, 57(1), 15-20. https://revistas.usp.br/rimtsp/article/view/100891