Molluscicidal effect of Euphorbia umbellata (Pax) Bruyns latex on Biomphalaria glabrata, Schistosoma mansoni host snail

Authors

  • Luciana Patrícia Lima Alves Pereira Universidade Federal do Maranhão
  • Clarice Noleto Dias Universidade Federal do Maranhão
  • Milena Valadar Miranda Universidade Federal do Maranhão
  • Wellyson da Cunha Araújo Firmo Universidade Federal do Maranhão
  • Carliane dos Santos Rosa Universidade Federal do Maranhão; Departamento de Farmácia
  • Priscila Freitas Santos Universidade Federal do Maranhão; Departamento de Farmácia
  • Maria Cristiane Aranha Brito Universidade Federal do Maranhão
  • Fernanda Oliveira Sousa Araruna Universidade Federal do Maranhão
  • Felipe Bastos Araruna Universidade Federal do Maranhão
  • Nêuton Silva-Souza Universidade Estadual do Maranhão; Departamento de Química e Biologia
  • Denise Fernandes Coutinho Universidade Federal do Maranhão; Departamento de Farmácia

Keywords:

Plant product, Toxicity, Biomphalaria glabrata, Schistosomiasis, Schistosoma mansoni, Molluscicidal effect

Abstract

Euphorbia umbellata (Pax) Bruyns is an easily cultivated shrub, with occurrence in the tropical regions of the American and African continents. Chemical studies have revealed that the latex of this plant is rich in terpene compounds, which are highly toxic to snails Biomphalaria glabrata (Basommatophora: Planorbidae). The aim of this study was to evaluate the chemical composition and molluscicidal activity of the latex produced by E. umbellata, as well as the safety of its application in aquatic environments. The concentration of latex that killed 90% of the exposed snails after 24 h exposure (LC90) was 3.69 mg/L. Toxicity bioassays using Danio rerio (zebrafish) revealed that these animals were less susceptible to latex than planorbids. However, it is important to perform other toxicity tests to ensure the feasibility of using latex to control populations of mollusks that contribute to schistosomiasis transmission. A phytochemical screening performed with the E. umbellata latex identified the triterpenoid and coumarin class. Further studies are warranted to isolate, identify, and test the active compounds of E. umbellata latex in B. glabrata.

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Published

2017-01-01

Issue

Section

Brief Communication

How to Cite

Molluscicidal effect of Euphorbia umbellata (Pax) Bruyns latex on Biomphalaria glabrata, Schistosoma mansoni host snail. (2017). Revista Do Instituto De Medicina Tropical De São Paulo, 59, e85. https://revistas.usp.br/rimtsp/article/view/143765