Hand, foot and mouth disease and herpangina caused by enterovirus A71 infections

a review of enterovirus A71 molecular epidemiology, pathogenesis, and current vaccine development

Authors

  • Yu-Kang Chang Chi-Mei Medical Center
  • Kou-Huang Chen Sanming University, School of Mechanical & Electronic Engineering
  • Kow-Tong Chen Tainan Municipal Hospital (Managed by Show Chwan Medical Care Corporation)

Keywords:

Hand, foot and mouth disease, Herpangina, Enterovirus A71, Vaccine

Abstract

Enterovirus A71 (EV-A71) infections are one of the main etiological agents of hand, foot and mouth disease (HFMD) and herpangina worldwide. EV-A71 infection is a life-threatening communicable disease and there is an urgent global need for the development of vaccines for its prevention and control. The morbidity rate of EV-A71 infection differs between countries. The pathogen’s genetic lineages are undergoing rapid evolutionary changes. An association between the occurrence of EV-A71 infection and the circulation of different genetic strains of EV-A71 virus has been identified around the world. In this review, we present and discuss the molecular epidemiology and pathogenesis of the human disease caused by EV-A71 infection, as well as current prospects for the development of an EV-A71 vaccine.

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Published

2018-11-08

Issue

Vol. 60 (2018)

Section

Review

How to Cite

Chang, Y.-K., Chen, K.-H., & Chen, K.-T. (2018). Hand, foot and mouth disease and herpangina caused by enterovirus A71 infections: a review of enterovirus A71 molecular epidemiology, pathogenesis, and current vaccine development. Revista Do Instituto De Medicina Tropical De São Paulo, 60, e70. https://revistas.usp.br/rimtsp/article/view/151629