Chagas disease cardiomyopathy: current concepts of an old disease

  • Angelina M.B. Bilate New York University School of Medicine; Institute of Biomolecular Medicine
  • Edecio Cunha-Neto Millennium Institutes; Institute for Investigation in Immunology
Keywords: Chagas disease, Cardiomyopathy, Autoimmune disease, Pathogenesis

Abstract

Chagas disease continues to be a significant public health problem, as ca. 10 million people are still infected with T. cruzi in Latin America. Decades after primary infection, 30% of individuals can develop a form of chronic inflammatory cardiomyopathy known as Chagas disease cardiomyopathy (CCC). Data from both murine models and human studies support the view that an autoimmune response as well as a parasite-driven immune response involving inflammatory cytokines and chemokines may both play a role in generating the heart lesions leading to CCC. This review aims to summarize recent advances in the understanding of the immunopathogenesis of Chagas disease cardiomyopathy.

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Published
2008-04-01
How to Cite
Bilate, A., & Cunha-Neto, E. (2008). Chagas disease cardiomyopathy: current concepts of an old disease . Revista Do Instituto De Medicina Tropical De São Paulo, 50(2), 67-74. Retrieved from http://www.revistas.usp.br/rimtsp/article/view/31154
Section
Invited review