Hemophagocytic syndrome associated with hepatitis A: case report and literature review

  • Felipe Francisco Tuon University of São Paulo Medical School; Department of Infectious and Parasitic Diseases
  • Virginia Soares Gomes University of São Paulo Medical School; Department of Infectious and Parasitic Diseases
  • Valdir Sabbaga Amato University of São Paulo Medical School; Hospital das Clínicas; Infectious and Parasitic Diseases Clinic
  • Maria Esther Graf University of São Paulo Medical School; Department of Infectious and Parasitic Diseases
  • Guilherme Henrique Hencklain Fonseca University of São Paulo Medical School; Department of Hematology
  • Carolina Lazari University of São Paulo Medical School; Department of Infectious and Parasitic Diseases
  • Antonio Carlos Nicodemo University of São Paulo Medical School; Department of Infectious and Parasitic Diseases
Keywords: Hemophagocytic syndrome, Hemophagocytosis, Viral-associated hemophagocytic syndrome, Hepatitis A virus, Intravenous immunoglobulin, Thrombocytopenia, Pancytopenia

Abstract

Virus-Associated Hemophagocytic Syndrome (VAHS) is a severe hematological disorder related to some viral infections. It is an illness characterized by persistent fever, pancytopenia, splenomegaly, hyperferritinemia and, the most important, hemophagocytosis observed in the bone marrow, liver and/or lymph nodes. VAHS associated with hepatitis A virus infection is rarely described, despite the high incidence of this viral infection in the population in general. There is no consensus in the literature regarding the optimal treatment of VAHS. In this article the clinical features, presumed pathogenesis, diagnostic criteria and treatment of VAHS are discussed, including description of cases of VAHS related to hepatitis A virus infection found in the medical literature.

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Published
2008-04-01
How to Cite
Tuon, F., Gomes, V., Amato, V., Graf, M., Fonseca, G., Lazari, C., & Nicodemo, A. (2008). Hemophagocytic syndrome associated with hepatitis A: case report and literature review . Revista Do Instituto De Medicina Tropical De São Paulo, 50(2), 123-127. Retrieved from http://www.revistas.usp.br/rimtsp/article/view/31165
Section
Case Reports