Seroconvertion to hepatitis B vaccine after weight reduction in obese non-responder

  • Maria Isabel Saraiva Dinelli Federal University of São Paulo; , Division of Pediatric Infectious Diseases; Department of Pediatrics
  • Maria Isabel de Moraes-Pinto Federal University of São Paulo; , Division of Pediatric Infectious Diseases; Department of Pediatrics
Keywords: Hepatitis B, Vaccine, Non-responder, Obesity, Gastroplasty

Abstract

Decreased responses to hepatitis B vaccine have been associated with some host conditions including obesity. Susceptible non-responders to a primary three-dose vaccine series should be revaccinated. Those who maintain a non-responder condition after revaccination with three vaccine doses are unlikely to develop protection using more doses. This is a description of an obese woman who received six doses of hepatitis B vaccine and persisted as a non-responder. She was submitted to a vertical banded gastroplasty Roux-en-Y gastric bypass Capellas's technique. After weight reduction, she received three additional doses of vaccine and seroconverted. Further studies should help clarify the need to evaluate antibody levels and eventually revaccinate the increasing population of individuals who undergo weight reduction.

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Published
2008-04-01
How to Cite
Dinelli, M., & Moraes-Pinto, M. (2008). Seroconvertion to hepatitis B vaccine after weight reduction in obese non-responder . Revista Do Instituto De Medicina Tropical De São Paulo, 50(2), 129-130. Retrieved from http://www.revistas.usp.br/rimtsp/article/view/31166
Section
Case Reports