Antiretroviral activity of protease inhibitors against Toxoplasma gondii

Authors

  • Lianet Monzote Institute of Tropical Medicine ‘Pedro Kouri’; Parasitology Department
  • Marta Rodríguez Institute of Tropical Medicine ‘Pedro Kouri’; Parasitology Department
  • Yenisey Alfonso Institute of Tropical Medicine ‘Pedro Kouri’; Parasitology Department
  • Raymundo Cox Institute of Tropical Medicine ‘Pedro Kouri’; Parasitology Department

Keywords:

Toxoplasma gondii, Antiretroviral protease inhibitors, Toxoplasmic encephalitis

Abstract

The introduction of highly active antiretroviral therapy (HAART) has caused a marked reduction in the occurrence and severity of parasitic infections, including the toxoplasmic encephalitis (TE). These changes have been attributed to the restoration of cell-mediated immunity. This study was developed to examine the activity of six antiretroviral protease inhibitors (API) on Toxoplasma gondii tachyzoites. The six API showed anti-Toxoplasma activity, with IC50 value between 1.4 and 6.6 µg/mL. Further studies at the molecular level should be performed to clarify if the use of API could be beneficial or not for AIDS patients with TE.

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Published

2013-02-01

Issue

Vol. 55 No. 1 (2013)

Section

Technical Report

How to Cite

Monzote, L., Rodríguez, M., Alfonso, Y., & Cox, R. (2013). Antiretroviral activity of protease inhibitors against Toxoplasma gondii . Revista Do Instituto De Medicina Tropical De São Paulo, 55(1), 65-67. https://revistas.usp.br/rimtsp/article/view/53541