Evaluation of WGA and Concanavalin A (Con A) lectin as biomarkers of hepatosplenic schistosomiasis in human biopsies with no evidence of egg-granuloma system

Authors

  • Moacyr Jesus Barreto de Melo Rêgo Federal University of Pernambuco; Keizo Asami Immunopathology Laboratory
  • Gabriela Souto Vieira-De-Mello Federal University of Pernambuco; Keizo Asami Immunopathology Laboratory
  • Cláudio Witaker Araújo Federal University of Pernambuco; Keizo Asami Immunopathology Laboratory
  • Maria do Socorro de Mendonça Cavalcanti Pernambuco University; Biological Science Institute; Physiology Department
  • Eduardo Isidoro Carneiro Beltrão Federal University of Pernambuco; Biological Science Center; Biochemistry Department

Abstract

Introduction: Colonic lesions are predominant in patients with schistosomiasis. However, carbohydrate alterations in colonic schistosomiasis remain unclear. Lectin-ligands allow us to identify changes in the saccharide patterns of cells. Methods: Biopsies of descending and rectosigmoid colon of patients were submitted to WGA and Con A lectin histochemistry. Results: WGA stained stroma and gland cells of descending colon and rectosigmoid tissues in a granular strong cytoplasmatic pattern in schistosomiasis specimens differing from normal control and Con A failing to recognize all samples analyzed. Conclusions: WGA ligands are expressed differently in patients with hepatosplenic schistosomiasis and no evidence of egg-granuloma system.

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Published

2013-06-01

Issue

Vol. 55 No. 3 (2013)

Section

Brief Communication

How to Cite

Rêgo, M. J. B. de M., Vieira-De-Mello, G. S., Araújo, C. W., Cavalcanti, M. do S. de M., & Beltrão, E. I. C. (2013). Evaluation of WGA and Concanavalin A (Con A) lectin as biomarkers of hepatosplenic schistosomiasis in human biopsies with no evidence of egg-granuloma system . Revista Do Instituto De Medicina Tropical De São Paulo, 55(3), 213-215. https://revistas.usp.br/rimtsp/article/view/78639