ESTABLISHING THE REFERENCE RANGE FOR T LYMPHOCYTES SUBPOPULATIONS IN ADULTS AND CHILDREN FROM BRAZIL

Authors

  • Alex Jose Leite Torres Federal University of Bahia
  • Ana Luiza Dias Angelo Federal University of Bahia
  • Marcio Oliveira Silva Federal University of Bahia
  • Milena de Carvalho Bastos Federal University of Bahia
  • Denise Ferreira de Souza Brazilian Ministry of Health; AIDS and SDT National Program
  • Lilian Amaral Inocencio Brazilian Ministry of Health; AIDS and SDT National Program
  • Jose Alexandre Rodrigues de Lemos Federal University of Para; HEMOPA Foundation; Hematology and Hemotherapy Center from state of Para
  • Ruy S. Junior Central Laboratory from Goias
  • Andrea Cauduro de Castro Hospital Nossa Senhora da Conceicao
  • Patricia Vianna Bonnini Palma Hemotherapy Center Foundation from Ribeirao Preto; Hematology
  • Loredana Ceci Infectious Diseases Laboratory
  • Eduardo Martins Netto Federal University of Bahia
  • Carlos Brites Federal University of Bahia

Abstract

SUMMARY In Brazil, the existing reference values for T-lymphocytes subsets are based on data originated in other countries. There is no local information on normal variation for these parameters in Brazilian adults and children. We evaluated the normal variation found in blood donors from five large Brazilian cities, in different regions, and in children living in Salvador, and Rio de Janeiro. All samples were processed by flow cytometry. The results were analyzed according to region, gender, and lifestyle of blood donors. A total of 641 adults (63% males), and 280 children (58% males) were involved in the study. The absolute CD3+, and CD4+ cells count were significantly higher for females (adults and children). Higher CD4+ cell count in adults was associated with smoking, while higher CD8+ count was found among female children. Higher counts, for all T-cells subsets, were detected in blood donors from southeast / south regions while those living in the northern region had the lowest values. Individuals from midwestern and northeastern regions had an intermediate count for all these cells subsets. However, these differences did not reach statistical significance. In Brazil, gender and smoking, were the main determinants of differences in T-lymphocytes reference values.

Downloads

Download data is not yet available.

Downloads

Published

2013-09-01

How to Cite

Torres, A. J. L., Angelo, A. L. D., Silva, M. O., Bastos, M. de C., Souza, D. F. de, Inocencio, L. A., Lemos, J. A. R. de, S. Junior, R., Castro, A. C. de, Palma, P. V. B., Ceci, L., Netto, E. M., & Brites, C. (2013). ESTABLISHING THE REFERENCE RANGE FOR T LYMPHOCYTES SUBPOPULATIONS IN ADULTS AND CHILDREN FROM BRAZIL . Revista Do Instituto De Medicina Tropical De São Paulo, 55(5), 323-328. Retrieved from http://www.revistas.usp.br/rimtsp/article/view/78666

Issue

Section

Immunology