BODY WEIGHT AS A DETERMINANT OF CLINICAL EVOLUTION IN HAMSTERS (Mesocricetus auratus) INFECTED WITH Leishmania (Viannia) panamensis

Authors

  • Angela Maria Gomez-Galindo Universidad Nacional de Colombia; Sciences Faculty; Immunotoxicology Research Group; Pharmacy Department
  • Lucy Gabriela Delgado-Murcia Universidad Nacional de Colombia; Sciences Faculty; Immunotoxicology Research Group; Pharmacy Department

Abstract

SUMMARY The clinical outcome of infection with Leishmania species of the subgenus Viannia in hamster model (Mesocricetus auratus) has shown to be different depending on experimental protocol. Body weight has been a relevant determinant of the clinical outcome of the infection in hamsters with visceral leishmaniasis but its importance as a clinical parameter in hamsters with cutaneous leishmaniasis is not known. In this study, the clinical evolution of infection with L. (V) panamensis was evaluated in juvenile and adult male hamsters during 11 weeks by comparing clinical parameters such as attitude, temperature, respiratory rate, appearance of the stool, and body weight between infected and non-infected groups. Results showed that body weight decreased in adult hamsters after infection by L. (V) panamensis; this observation supports the use of body weight as an additional parameter to define the management or treatment of cutaneous leishmaniasis in infected adult hamsters used as an animal experimental model for leishmaniasis.

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Published

2013-09-01

How to Cite

Gomez-Galindo, A. M., & Delgado-Murcia, L. G. (2013). BODY WEIGHT AS A DETERMINANT OF CLINICAL EVOLUTION IN HAMSTERS (Mesocricetus auratus) INFECTED WITH Leishmania (Viannia) panamensis . Revista Do Instituto De Medicina Tropical De São Paulo, 55(5), 357-361. Retrieved from http://www.revistas.usp.br/rimtsp/article/view/78671

Issue

Section

Leishmaniasis