Mortality trend due to Hepatitis B and C in the city of São Paulo, 2002–2016
DOI:
https://doi.org/10.11606/s1518-8787.2020054002231Keywords:
Hepatitis B., Hepatitis C, Mortality, trends, Time Series StudiesAbstract
OBJECTIVE: To describe mortality due to hepatitis B and C as underlying cause in the municipality of São Paulo, verifying the trend of these rates, and to assess the association of these diseases with others, from 2002 to 2016. METHODS: This is a time series study on mortality due to hepatitis B and C according to sex, with data from the Sistema de Informação de Mortalidade (SIM – Mortality Information Sistem). Prais Winsten regression was used in rate trend analysis. RESULTS: The findings of this study showed a trend of decline of mortality from hepatitis B and C in recent years, particularly among males. These infections were important associated causes of liver cell carcinoma and HIV. The proportion of deaths under 70 years of age stands out. CONCLUSIONS: The study provides a baseline for research on mortality trend and the impact of interventions, given the history of expanded detection and supply of treatments, including the most recent antivirals in Brazil, since 2015.
References
World Health Organization. Prevention and control of viral hepatitis infection: framework for global action. Geneva: WHO; 2012.
Pereira LMMB, Martelli CMT, Méchan-Hamann E, Montarroyos UR, Braga MC, Lima MLC, et al. Population-based multicentric survey of hepatitis B infection and risk factor differences among three regions in Brazil. Am J Trop Med Hyg. 2009;81(2):240-7. https://doi.org/10.4269/ajtmh.2009.81.240
Pereira LMMB, Martelli CMT, Moreira RC, Merchan-Hamman E, Stein AT, Cardoso MRA, et al. Prevalence and risk factors of Hepatitis C virus infection in Brazil, 2005 through 2009: a cross-sectional study. BMC Infect Dis. 2013;13:60. https://doi.org/10.1186/1471-2334-13-60
Ximenes RAA, Figueiredo GM, Cardoso MRA, Stein AT, Moreira RC, Coral G, et al. Population-based multicentric survey of Hepatitis B infection and risk factors in the north, south, and southeast regions of Brazil, 10-20 years after the beginning of vaccination. Am J Trop Med Hyg. 2015;93(6):1341-8. https://doi.org/10.4269/ajtmh.15-0216
Ministério da Saúde (BR), Secretaria de Vigilância em Saúde, Departamento de DST/aids e Hepatites Virais. Plano para Eliminação da Hepatite C no Brasil. Brasília, DF; 2019.
Benzaken AS, Girade R, Catapan E, Pereira GFM, Almeida EC, Vivaldini S, et al. Hepatitis C disease burden and strategies for elimination by 2030 in Brazil. A mathematical modeling approach. Braz J Infect Dis. 2019;23(3):182-90. https://doi.org/10.1016/j.bjid.2019.04.010
World Health Organization. Hepatitis B. Geneva: WHO; 2020 [cited 2020 Sep 9]. Available from: https://www.who.int/news-room/fact-sheets/detail/hepatitis-b
World Health Organization. Hepatitis C. WHO; Geneva; WHO; 2020 [cited 2020 Sep 9]. Available from: https://www.who.int/news-room/fact-sheets/detail/hepatitis-c
GBD 2016 Causes of Death Collaborators. Global, regional, and national agesex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1151-1210. https://doi.org/10.1016/S0140-6736(17)32152-9
Tauil MC, Amorim TR, Pereira GFM, Araújo WN. Mortalidade por hepatite viral B no Brasil, 2000-2009. Cad Saude Publica. 2012;28(3):472-8. https://doi.org/10.1590/S0102-311X2012000300007
Fundação SEADE. Informações dos Municípios Paulistas. São Paulo; 2019 [cited 2019 Nov 1]. Available from: http://www.imp.seade.gov.br/frontend/#/
Instituto Brasileiro de Geografia e Estatística. Índice de Desenvolvimento Humano Municipal – 2010. Rio de Janeiro: IBGE; 2010 [cited 2019 Nov 18]. Available from: https://cidades.ibge.gov.br/brasil/sp/sao-paulo/panorama
Ministério da Saúde (BR). DATASUS. Arquivo de dados do Sistema de Informação de Mortalidade do Estado de São Paulo do período de 2002 a 2016. Brasília, DF; 2019 [cited 2019 Nov 1]. Avaliable from: http://www2.datasus.gov.br/DATASUS/index. php?area=0901&item=1&acao=26
Prefeitura Municipal de São Paulo. Programa de Aprimoramento das Informações de Mortalidade. Coletânea de Textos dos boletins do PRO-AIM. São Paulo; 2003.
Organização Mundial da Saúde. CID-10. Classificação estatística internacional de doenças e problemas relacionados à saúde. 2.ed. São Paulo: Editora da Universidade de São Paulo;1997. v.1.
Laurenti R, Mello Jorge MHP. Atestado de óbito: aspectos médicos, estatísticos, éticos e jurídicos. São Paulo: Conselho Regional de Medicina do Estado de São Paulo; 2015.
Ministério da Saúde (BR), Fundação Nacional da Saúde. Manual de Instruções para o preenchimento da declaração de óbito. 3. ed. Brasília, DF: FUNASA; 2001.
Antunes JLF, Cardoso MRA. Uso da análise de séries temporais em estudos epidemiológicos. Epidemiol Serv Saude. 2015;24(3):565-76. https://doi.org/10.5123/S1679-49742015000300024
Ly KN, Xing J, Klevens RM, Jiles RB, Ward JW, Holmberg SD. The increasing burden of mortality from viral hepatitis in the United States between 1999 and 2007. Ann Intern Med. 2012;156(4):271-8. https://doi.org/10.7326/0003-4819-156-4-201202210-00004
Chang MH, Chen CJ, Lai MS, Hsu HM, Wu TC, Kong MS, et al. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. N Engl J Med. 1997;336(26):1855-9. https://doi.org/10.1056/NEJM19970626336260
Ni YH, Chang MH, Huang LM, Chen HL, Hsu HY, Chiu TY, et al. Hepatitis B virus infection in children and adolescents in a hyperendemic area: 15 years after mass hepatitis B vaccination. Ann Intern Med. 2001;135(9):796-800. https://doi.org/10.7326/0003-4819-135-9-200111060-00009
Grirnsven GJ, Vroome EM, Goudsmit J, Coutinho RA. Changes in sexual behavior and the fall in incidence of HIV infection among homosexual men. BMJ. 1989;298(6668):218-21. https://doi.org/10.1136/bmj.298.6668.218
Alter MJ, Hadler SC, Margolis HS, Alexander J, Hu PY, Judson FN, et al. The changing epidemiology of hepatitis b in the United States. Needs for alternative vaccination strategies. JAMA. 1990;263(9):1218-22. https://doi.org/10.1001/jama.1990.03440090052025
Marotta P, Hueppe D, Zehnter E, Kwo P, Jacobson I. Efficacy of chronic hepatitis C therapy in community-based trials. Clin Gastroenterol Hepatol. 2009;7(10):1028-36. https://doi.org/10.1016/j.cgh.2009.05.003
Hansen N, Obel N, Christensen PB, Kjaer M, Laursen AL, Krarup HB, et al. Effectiveness of treatment with pegylated interferon and ribavirin in an unselected population of patients with chronic hepatitis C: a Danish nationwide cohort study. BMC Infect Dis. 2011;11:177. https://doi.org/10.1186/1471-2334-11-177
Ford N, Kirby C, Singh K, Mills EJ, Cooke G, Kamarulzaman A, et al. Chronic hepatitis C treatment outcomes in low- and middle-income countries: a systematic review and meta-analysis. Bull World Health Organ. 2012;90(7):540-50. https://doi.org/10.2471/BLT.11.097147
Ministério da Saúde (BR), Secretaria de Vigilância em Saúde. Departamento de DST, Aids e Hepatites Virais. Protocolo clínico e diretrizes terapêuticas para Hepatite C e coinfecções. Brasília, DF; 2015.
Razavi H, Elkhoury AC, Elbasha E, Estes C, Pasini K, Poynard T, et al. Chronic hepatitis C virus (HCV) disease burden and cost in the United States. Hepatology. 2013;57(6):2164-70. https://doi.org/10.1002/hep.26218
Mahajan R, Xing J, Liu SJ, LyKN, Moorman AC, Rupp L, et al. Mortality among persons in care with hepatitis C virus infection: the Chronic Hepatitis Cohort Study (CheCS), 2006–2010. Clin Infect Dis. 2014;58(8):1055-61 https://doi.org/10.1093/cid/ciu077
Pinchoff J, Drobnik A, Bornschlegel K, Braunstein S, Chan C, Varma JK et al. Deaths among people with hepatitis C in New York City, 2000-2011. Clin Infect Dis. 2014;58(8):1047-54. https://doi.org/10.1093/cid/ciu075
Ministério da Saúde (BR), Agência Nacional de Vigilância Sanitária. Portaria Nº 4, de 7 de fevereiro de 1986. Normaliza o uso e reutilização de materiais médico-hospitalares descartáveis no país. Diário Oficial União. 12 fev 1986;(28).
Ly KN, Xing J, Klevens RM, Jiles RB, Holmberg SD. Causes of death and characteristics of decedents with viral hepatitis, United States, 2010. Clin Infect Dis. 2014;58(1):40-9. https://doi.org/10.1093/cid/cit642
Perz JF, Armstrong GL, Farrington LA, Hutin YJF, Bell BP. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol. 2006;45(4):529-38. https://doi.org/10.1016/j.jhep.2006.05.013
Sulkowski MS. Viral hepatitis and HIV coinfection. J Hepatol. 2008;48(2):353-67. https://doi.org/10.1016/j.jhep.2007.11.009
Walter SR, Thein HH, Amin J, Gidding HF, Ward K, Law MG, et al. Trends in mortality after diagnosis of hepatitis B or C infection: 1992-2006. J Hepatol. 2011;54(5):879-86. https://doi.org/10.1016/j.jhep.2010.08.035
Lédinghen V, Barreiro P, Foucher J, Labarga P, Castéra L, Vispo ME, et al. Liver fibrosis on account of chronic hepatitis C is more severe in HIV-positive than HIV-negative patients despite antiretroviral therapy. J Viral Hepat. 2008;15(6):427-33. https://doi.org/10.1111/j.1365-2893.2007.00962.x
Redelings MD, Sorvillo F, Simon P. A comparison of underlying cause and multiple causes of death. Epidemiology. 2006;17(1):100-3. https://doi.org/10.1097/01.ede.0000187177.96138.c6
Oliveira BZ, Gotlieb SLD, Laurenti R, Mello Jorge MHP. Mortalidade feminina por hipertensão: análise por causas múltiplas. Rev Bras Epidemiol. 2009;12(4):556-65. https://doi.og/10.1590/S1415-790X2009000400006
Ministério da Saúde (BR), Secretaria de Vigilância em Saúde. Departamento de Vigilância, Prevenção e Controle das Infecções Sexualmente Transmissíveis, do HIV/Aids e das Hepatites Virais. Protocolo clínico e diretrizes terapêuticas para Hepatite C e coinfecções; Brasília, DF; 2019.
Kabiri M, Jazwinski AB, Roberts MS, Schaefer AJ, Chhatwal J. The changing burden of hepatitis C virus infection in the United States: model-based predictions. Ann Intern Med. 2014;161(3):170-80. https://doi.org/10.7326/M14-0095
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Copyright (c) 2020 Ana Paula Sayuri Sato, Inês Kazue Koizumi, Norma Suely de Oliveira Farias, Célia Regina Ciccolo da Silva, Maria Regina Alves Cardoso, Gerusa Maria Figueiredo
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