Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population

Authors

  • Sema Inanir Gaziosmanpasa University; Faculty of Medicine; Department of Psychiatry
  • Serbulent Yigit Gaziosmanpasa University; Faculty of Medicine; Department of Medical Biology
  • Feryal Çam Çelikel Gaziosmanpasa University; Faculty of Medicine; Department of Psychiatry
  • Omer Ates Gaziosmanpasa University; Faculty of Medicine; Department of Medical Biology
  • Serap Erdogan Taycan Gaziosmanpasa University; Faculty of Medicine; Department of Psychiatry
  • Ayse Feyda Nursal Giresun University; Faculty of Medicine; Department of Medical Genetics
  • Akin Tekcan Ahi Evran University; School of Health
  • Aydin Rustemoglu Gaziosmanpasa University; Faculty of Medicine; Department of Medical Biology
  • Gul Dursun Gaziosmanpasa University; Faculty of Medicine; Department of Medical Biology
  • Ahmet Inanir Gaziosmanpasa University; Faculty of Medicine; Department of Physical Medicine and Rehabilitation

DOI:

https://doi.org/10.1590/0101-60830000000077

Abstract

Background Major depressive disorder (MDD) is a complex disease and a significant health problem that is prevalent across the world. Angiotensin-converting enzyme (ACE) has an important role in renin-angiotensin system (RAS) and converts inactive angiotensin I to a potent vasopressor and aldosterone-stimulating peptide angiotensin II. Levels of ACE in plasma vary according to the insertion/deletion (I/D) polymorphism of ACE gene. Objective The aim of the current study was to examine the influence ACE gene I/D variations on the risk of MDD. Methods In the present case-control study, we analyzed ACE I/D polymorphism in 346 MDD patients and 210 healthy subjects using polymerase chain reaction technique. Results Comparing the two groups, no significant difference was observed with regard to either genotype distributions or allele frequencies of the I/D polymorphism of ACE gene. Discussion Our findings suggest that the ACE I/D polymorphism is not associated with MDD in Turkish case-control study. Further studies are still needed.

Downloads

Download data is not yet available.

Downloads

Published

2016-04-01

Issue

Vol. 43 No. 2 (2016)

Section

Original Articles

License

Once accepted for publication, the manuscript becomes permanent property of the Archives of Clinical Psychiatry. This copyright transfer subsumes exclusive and unlimited entitlement of the Archives of Clinical Psychiatry to publish and distribute the full contents of articles in whichever publishing medium, including press and electronic media, in Brazil and abroad.

Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population . (2016). Archives of Clinical Psychiatry (São Paulo), 43(2), 27-30. https://doi.org/10.1590/0101-60830000000077