Striatal monoamines levels during status epilepticus

Authors

  • Rivelilson Mendes de Freitas Universidade Federal do Ceará
  • Glauce Socorro Barros Viana Universidade Federal do Ceará; Laboratório de Neurofarmacologia
  • Marta Maria de França Fonteles Universidade Federal do Ceará; Laboratório de Neurofarmacologia

DOI:

https://doi.org/10.1590/S0101-60832003000300001

Keywords:

Dopamine, Serotonine, Seizures, Striatum

Abstract

The purpose of the present work to investigate the striatal neurotransmissors level in adult rats after status epilepticus induced by pilocarpine. Wistar rats were treated with a single dose of pilocarpine (400 mg/kg; s.c.; P400) and the controls received saline. Adult animals were closed observed for behavioural changes during 1h. In this period, the animals that developed status epilepticus and survive this acute phase of seizures had the brains removed and striatal neurotransmissors level determiden by HPLC. The concentration of dopamine, serotonine, dihydroxyphenylacetic acid was reduced and an concentration increase in 5-hydroxyindolacetic acid. Didn't observed alteration in 4-hydroxy-3-methoxy-phenylacetic acid. These results suggest that cholinergic activation can interage with dopaminergic and serotonergic systems in acute phase of the convulsive process in rat mature striatum.

Downloads

Download data is not yet available.

Downloads

Published

2003-01-01

Issue

Vol. 30 No. 3 (2003)

Section

Original Articles

License

Once accepted for publication, the manuscript becomes permanent property of the Archives of Clinical Psychiatry. This copyright transfer subsumes exclusive and unlimited entitlement of the Archives of Clinical Psychiatry to publish and distribute the full contents of articles in whichever publishing medium, including press and electronic media, in Brazil and abroad.

Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

Striatal monoamines levels during status epilepticus . (2003). Archives of Clinical Psychiatry, 30(3), 76-79. https://doi.org/10.1590/S0101-60832003000300001