Bupropion efficacy in the treatment of ADHD: a systematic review and critical analysis of evidences

Authors

  • Daniel Segenreich Universidade Federal do Rio de Janeiro; Instituto de Psiquiatria
  • Paulo Mattos Universidade Federal do Rio de Janeiro; Instituto de Psiquiatria

DOI:

https://doi.org/10.1590/S0101-60832004000300001

Keywords:

Bupropion, attention deficit, ADHD, attention deficit hyperactivity disorder

Abstract

OBJECTIVE: To review in a systematic way the use of bupropion in the treatment of Attention-Deficit Hyperactivity Disorder (ADHD). SOURCE OF DATA: literature review from 1990 to 2003 using Medline e Lilacs. RESULTS: Four studies with children and adolescents were obtained, one of them evaluating a sample in which there was comorbidity with depression. Five studies with adults were obtained; one with a sample in which there was comorbidity with substance abuse, another with depression and another one with Bipolar Disorder. CONCLUSION: Methodological limitations of all presently available studies in literature do not allow conclusions on the bupropion degree of efficacy when compared to first-line medication (stimulants), besides the significant difference to placebo. Yet, there is some evidence of a lower effect size. Studies indicate a quite satisfactory profile of adverse events.

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Published

2004-01-01

Issue

Vol. 31 No. 3 (2004)

Section

Reviews of Literature

License

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Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

Bupropion efficacy in the treatment of ADHD: a systematic review and critical analysis of evidences . (2004). Archives of Clinical Psychiatry, 31(3), 117-123. https://doi.org/10.1590/S0101-60832004000300001