Farmacogenética do tratamento da depressão: busca de marcadores moleculares de boa resposta aos antidepressivos

Authors

  • Ivanor Velloso Meira Lima Universidade Federal de Pernambuco; Departamento de Neuropsiquiatria; Núcleo de Assistência, Ensino e Pesquisa em Transtornos Afetivos
  • Everton Botelho Sougey Universidade Federal de Pernambuco; Departamento de Neuropsiquiatria; Núcleo de Assistência, Ensino e Pesquisa em Transtornos Afetivos
  • Homero Pinto Vallada Filho Universidade de São Paulo; Faculdade de Medicina; Instituto de Psiquiatria; Laboratório de Neurociências (LIM 27)

DOI:

https://doi.org/10.1590/S0101-60832004000100007

Keywords:

Antidepressant, pharmacogenetics, polymorphisms

Abstract

The present article reviews the studies on genetic determinants for drug response to the treatment of depression. These investigations assess the individual differences in the pharmacokinetic mechanisms - such as the genetic variants of genes coding for drug-metabolizing enzymes - and in the pharmacodynamics, looking at the genetic variants of genes coding for drug targets. The authors conclude that the knowledge about the functional variants of the genes coding for antidepressant metabolizing enzymes such as CYP2D6, or genes coding for antidepressant targets such as the serotonin transporter protein (5-HTT), could assist in individualizing the selection of medication and dosage for depression treatment.

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Published

2004-01-01

Issue

Vol. 31 No. 1 (2004): Genoma, genética e Psiquiatria

Section

Original Articles

License

Once accepted for publication, the manuscript becomes permanent property of the Archives of Clinical Psychiatry. This copyright transfer subsumes exclusive and unlimited entitlement of the Archives of Clinical Psychiatry to publish and distribute the full contents of articles in whichever publishing medium, including press and electronic media, in Brazil and abroad.

Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

Farmacogenética do tratamento da depressão: busca de marcadores moleculares de boa resposta aos antidepressivos . (2004). Archives of Clinical Psychiatry, 31(1), 40-43. https://doi.org/10.1590/S0101-60832004000100007