Associations between genetic polymorphisms and bipolar disorder

Authors

  • Verônica de Medeiros Alves UFAL
  • Aline Cristine Pereira e Silva UFAL
  • Valfrido Leão de Melo Neto UFAL
  • Tiago Gomes de Andrade UFAL
  • Antonio Egidio Nardi UFAL

DOI:

https://doi.org/10.1590/S0101-60832012000100007

Keywords:

Bipolar disorder, genes, polymorphisms, heredity, gene ontology, association with bipolar disorder

Abstract

Bipolar disorder (BD) is a common disorder that affects approximately 1% of the population. It is associated with both chronic and acute severe features, such as low remission rates and a high prevalence of clinical and psychiatric comorbidities. The aim of the present article is to synthesize data from various articles that investigated genetic polymorphisms associated with BD. The 129 articles selected identified 79 (85.87%) genes associated with BD. This analysis identified the five genes that are the most cited in the literature: CANAC1C, DAOA, TPH2, ANK3 and DISC1. Of the 92 genes identified in these articles, 33 (35.87%) showed no association with BD. This analysis showed that, despite recent advances with respect to the role of genetic polymorphism in predisposition to BD, further research is still required to elucidate its influence on this disorder.

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Published

2012-01-01

Issue

Vol. 39 No. 1 (2012)

Section

Reviews of Literature

License

Once accepted for publication, the manuscript becomes permanent property of the Archives of Clinical Psychiatry. This copyright transfer subsumes exclusive and unlimited entitlement of the Archives of Clinical Psychiatry to publish and distribute the full contents of articles in whichever publishing medium, including press and electronic media, in Brazil and abroad.

Manuscripts are accepted with the understanding that the Editor and the editorial staff have the right to make revisions aimed at greater conciseness, clarity, and conformity with Journal style, of course without changing its content.

How to Cite

Associations between genetic polymorphisms and bipolar disorder . (2012). Archives of Clinical Psychiatry, 39(1), 34-39. https://doi.org/10.1590/S0101-60832012000100007