Comparação das respostas neuromusculares e bioquímicas entre pacientes com DPOC e indivíduos saudáveis

Autores

  • Natércia Ferreira de Queiroz Universidade Federal do Rio Grande do Norte
  • Rudolfo Hummel Gurgel Vieira Universidade Federal do Rio Grande do Norte
  • Wouber Hérickson de Brito Vieira Universidade Federal do Rio Grande do Norte
  • Zênia Trindade de Souto Araujo Universidade Federal do Rio Grande do Norte
  • Gerson Fonseca de Souza Universidade Federal do Rio Grande do Norte
  • Ivan Daniel Bezerra Nogueira Universidade Federal do Rio Grande do Norte
  • Telma Maria Araújo Moura Lemos Universidade Federal do Rio Grande do Norte
  • Patrícia Angélica de Miranda Silva Nogueira Universidade Federal do Rio Grande do Norte

DOI:

https://doi.org/10.11606/issn.2317-0190.v30i4a194247

Palavras-chave:

Doença Pulmonar Obstrutiva Crônica, Biomarcadores, Fadiga Muscular, Músculo Quadríceps

Resumo

Objetivo: Comparar as respostas neuromusculares e bioquímicas do dano e fadiga muscular do quadríceps femoral entre indivíduos com doença pulmonar obstrutiva crônica (DPOC) e saudáveis. Métodos: Estudo observacional, transversal e comparativo. A amostra foi composta por 18 indivíduos alocados em dois grupos distintos: Grupo DPOC (GD) e grupo saudáveis (GS), os quais foram avaliados por meio da espirometria, do desempenho neuromuscular do quadríceps, dos marcadores bioquímicos do dano e fadiga muscular, da fatigabilidade e da dor muscular. Resultados: Observou-se diferença estatisticamente significante na potência média entre o GD e GS (99,9 ± 21,0 vs 145,1 ± 51,5, respectivamente; p= 0,02) e uma tendência das médias de pico de torque (85,7 ± 24,4 vs 104,4 ± 31,0; p= 0,45) e trabalho total (1.305,5 ± 329,9 vs 1.671,5 ± 444,5; p= 0,06) serem menores no GD que no GS, respectivamente. A concentração da LDH imediatamente após o teste isocinético foi significantemente maior no GD que no GS (402,3 ± 33,6 vs 289,4 ± 33,6, respectivamente; p= 0,03). Conclusões: O presente estudo mostrou que pacientes com DPOC tem redução da capacidade de gerar força em um determinado período de tempo quando comparado a indivíduos saudáveis. A dosagem plasmática dos marcadores bioquímicos não permitiu confirmar que os pacientes com DPOC tem maior nível de dano muscular quando realizam exercício que os controles saudáveis.

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Referências

Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ, Bourbeau J, et al. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary. Am J Respir Crit Care Med. 2017;195(5):557-582. Doi: https://doi.org/10.1164/rccm.201701-0218PP

Soriano JB. An Epidemiological Overview of Chronic Obstructive Pulmonary Disease: What Can Real-Life Data Tell Us about Disease Management? COPD. 2017;14(sup1):S3-S7. Doi: https://doi.org/10.1080/15412555.2017.1286165

Diaz-Guzman E, Mannino DM. Epidemiology and prevalence of chronic obstructive pulmonary disease. Clin Chest Med. 2014;35(1):7-16. Doi: https://doi.org/10.1016/j.ccm.2013.10.002

Giacomell IL, Steidle LJM, Moreira FF, Meyer IV, Souza RG, Pincelli MP. Pacientes portadores de DPOC hospitalizados: análise do tratamento prévio. J Bras Pneumol. 2014;40(3):229-37. Doi: https://doi.org/10.1590/s1806-37132014000300005

Miranda EF, Leal-Junior EC, Marchetti PH, Dal Corso S. Acute effects of light emitting diodes therapy (LEDT) in muscle function during isometric exercise in patients with chronic obstructive pulmonary disease: preliminary results of a randomized controlled trial. Lasers Med Sci. 2014;29(1):359-65. Doi: https://doi.org/10.1007/s10103-013-1359-5

Castro AA, Kümpel C, Rangueri RC, Oliveira MD, Dornelles RA, Brito ER, et al. Daily activities are sufficient to induce dynamic pulmonary hyperinflation and dyspnea in chronic obstructive pulmonary disease patients. Clinics (Sao Paulo). 2012;67(4):319-25. Doi: https://doi.org/10.6061/clinics/2012(04)04

Miranda EF, Oliveira LV, Antonialli FC, Vanin AA, Carvalho PT, Leal-Junior EC. Phototherapy with combination of super-pulsed laser and light-emitting diodes is beneficial in improvement of muscular performance (strength and muscular endurance), dyspnea, and fatigue sensation in patients with chronic obstructive pulmonary disease. Lasers Med Sci. 2015;30(1):437-43. Doi: https://doi.org/10.1007/s10103-014-1690-5

Miranda EF, Malaguti C, Marchetti PH, Dal Corso S. Upper and lower limb muscles in patients with COPD: similarities in muscle efficiency but differences in fatigue resistance. Respir Care. 2014;59(1):62-9. Doi: https://doi.org/10.4187/respcare.02439

Al-Shair K, Kolsum U, Singh D, Vestbo J. The Effect of Fatigue and Fatigue Intensity on Exercise Tolerance in Moderate COPD. Lung. 2016;194(6):889-895. Doi: https://doi.org/10.1007/s00408-016-9931-y

Hamilton AL, Killian KJ, Summers E, Jones NL. Muscle strength, symptom intensity, and exercise capacity in patients with cardiorespiratory disorders. Am J Respir Crit Care Med. 1995;152(6 Pt 1):2021-31. Doi: https://doi.org/10.1164/ajrccm.152.6.8520771

Patel MS, Natanek SA, Stratakos G, Pascual S, Martínez-Llorens J, Disano L, et al. Vastus lateralis fiber shift is an independent predictor of mortality in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014;190(3):350-2. Doi: https://doi.org/10.1164/rccm.201404-0713LE

Swallow EB, Reyes D, Hopkinson NS, Man WD, Porcher R, Cetti EJ, et al. Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease. Thorax. 2007;62(2):115-20. Doi: https://doi.org/10.1136/thx.2006.062026

Marquis K, Debigaré R, Lacasse Y, LeBlanc P, Jobin J, Carrier G, et al. Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2002;166(6):809-13. Doi: https://doi.org/10.1164/rccm.2107031

Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J. 2009;33(5):1165-85. Doi: https://doi.org/10.1183/09031936.00128008

Brancaccio P, Lippi G, Maffulli N. Biochemical markers of muscular damage. Clin Chem Lab Med. 2010;48(6):757-67. Doi: https://doi.org/10.1515/CCLM.2010.179

American Thoracic Society/European Respiratory Society. ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med. 2002;166(4):518-624. Doi: https://doi.org/10.1164/rccm.166.4.518

Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982;14(5):377-81.

Scott J, Huskisson EC. Graphic representation of pain. Pain. 1976;2(2):175-84.

Cannon DT, Coelho AC, Cao R, Cheng A, Porszasz J, Casaburi R, et sl. Skeletal muscle power and fatigue at the tolerable limit of rampincremental exercise in COPD. J Appl Physiol (1985). 2016;121(6):1365-1373. Doi: https://doi.org/10.1152/japplphysiol.00660.2016

Buchowski MS, Simmons SF, Whitaker LE, Powers J, Beuscher L, Choi L, et al. Fatigability as a function of physical activity energy expenditure in older adults. Age (Dordr). 2013;35(1):179-87. Doi: https://doi.org/10.1007/s11357-011-9338-x

Maltais F, Decramer M, Casaburi R, Barreiro E, Burelle Y, Debigaré R, et al. An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014;189(9):e15-62. Doi: https://doi.org/10.1164/rccm.201402-0373ST

Bernard S, LeBlanc P, Whittom F, Carrier G, Jobin J, Belleau R, et al. Peripheral muscle weakness in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;158(2):629-34. Doi: https://doi.org/10.1164/ajrccm.158.2.9711023

Gosselink R, Troosters T, Decramer M. Distribution of muscle weakness in patients with stable chronic obstructive pulmonary disease. J Cardiopulm Rehabil. 2000;20(6):353-60. Doi: https://doi.org/10.1097/00008483-200011000-00004

Cielen N, Maes K, Gayan-Ramirez G. Musculoskeletal disorders in chronic obstructive pulmonary disease. Biomed Res Int. 2014;2014:965764. Doi: https://doi.org/10.1155/2014/965764

Ribeiro F, Lépine PA, Garceau-Bolduc C, Coats V, Allard É, Maltais F, et al. Test-retest reliability of lower limb isokinetic endurance in COPD: A comparison of angular velocities. Int J Chron Obstruct Pulmon Dis. 2015;10:1163-72. Doi: https://doi.org/10.2147/COPD.S81806

Pleguezuelos E, Esquinas C, Moreno E, Guirao L, Ortiz J, Garcia-Alsina J, et al. Muscular Dysfunction in COPD: Systemic Effect or Deconditioning? Lung. 2016;194(2):249-57. Doi: https://doi.org/10.1007/s00408-015-9838-z

Queiroz CF, Lemos AC, Bastos ML, Neves MC, Camelier AA, Carvalho NB, et al. Perfil inflamatório e imunológico em pacientes com DPOC: relação com a reversibilidade do VEF1. J Bras Pneumol. 2016;42(4):241-247. Doi: https://doi.org/10.1590/S1806-37562015000000122

Takeda M, Sato T, Hasegawa T, Shintaku H, Kato H, Yamaguchi Y, et al. The effects of cold water immersion after rugby training on muscle power and biochemical markers. J Sports Sci Med. 2014;13(3):616-23.

Glasgow PD, Ferris R, Bleakley CM. Cold water immersion in the management of delayedonset muscle soreness: is dose important? A randomised controlled trial. Phys Ther Sport. 2014;15(4):228-33. Doi: https://doi.org/10.1016/j.ptsp.2014.01.002

Felismino AS, Costa EC, Aoki MS, Ferraresi C, Araújo Moura Lemos TM, Brito Vieira WH. Effect of low-level laser therapy (808 nm) on markers of muscle damage: a randomized double-blind placebo-controlled trial. Lasers Med Sci. 2014;29(3):933-8. Doi: https://doi.org/10.1007/s10103-013-1430-2

Heavens KR, Szivak TK, Hooper DR, Dunn-Lewis C, Comstock BA, Flanagan SD, et al. The effects of high intensity short rest resistance exercise on muscle damage markers in men and women. J Strength Cond Res. 2014;28(4):1041-9. Doi: https://doi.org/10.1097/JSC.0000000000000236

Meijer K, Annegarn J, Lima Passos V, Savelberg HH, Schols AM, Wouters EF, et al. Characteristics of daily arm activities in patients with COPD. Eur Respir J. 2014;43(6):1631-41. Doi: https://doi.org/10.1183/09031936.00082513

Evans RA, Morgan MD. The systemic nature of chronic lung disease. Clin Chest Med. 2014;35(2):283-93. Doi: https://doi.org/10.1016/j.ccm.2014.02.009

Houben-Wilke S, Jörres RA, Bals R, Franssen FM, Gläser S, Holle R, et al. Peripheral Artery Disease and Its Clinical Relevance in Patients with Chronic Obstructive Pulmonary Disease in the COPD and Systemic Consequences-Comorbidities Network Study. Am J Respir Crit Care Med. 2017;195(2):189-197. Doi: https://doi.org/10.1164/rccm.201602-0354OC

Vieira WH, Ferraresi C, Perez SE, Baldissera V, Parizotto NA. Effects of low-level laser therapy (808 nm) on isokinetic muscle performance of young women submitted to endur-ance training: a randomized controlled clinical trial. Lasers Med Sci. 2012;27(2):497-504. Doi: https://doi.org/10.1007/s10103-011-0984-0

Hernández M, Zambom-Ferraresi F, Cebollero P, Hueto J, Cascante JA, Antón MM. The Relationships Between Muscle Power and Physical Activity in Older Men With Chronic Obstructive Pulmonary Disease. J Aging Phys Act. 2017;25(3):360-366. Doi: https://doi.org/10.1123/japa.2016-0144

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2023-12-31

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1.
Queiroz NF de, Vieira RHG, Vieira WH de B, Araujo ZT de S, Souza GF de, Nogueira IDB, et al. Comparação das respostas neuromusculares e bioquímicas entre pacientes com DPOC e indivíduos saudáveis. Acta Fisiátr. [Internet]. 31º de dezembro de 2023 [citado 20º de julho de 2024];30(4):218-24. Disponível em: https://www.revistas.usp.br/actafisiatrica/article/view/194247