Comparação das respostas neuromusculares e bioquímicas entre pacientes com DPOC e indivíduos saudáveis

Autores

  • Natércia Ferreira de Queiroz Universidade Federal do Rio Grande do Norte
  • Rudolfo Hummel Gurgel Vieira Universidade Federal do Rio Grande do Norte
  • Wouber Hérickson de Brito Vieira Universidade Federal do Rio Grande do Norte
  • Zênia Trindade de Souto Araujo Universidade Federal do Rio Grande do Norte
  • Gerson Fonseca de Souza Universidade Federal do Rio Grande do Norte
  • Ivan Daniel Bezerra Nogueira Universidade Federal do Rio Grande do Norte
  • Telma Maria Araújo Moura Lemos Universidade Federal do Rio Grande do Norte
  • Patrícia Angélica de Miranda Silva Nogueira Universidade Federal do Rio Grande do Norte

DOI:

https://doi.org/10.11606/issn.2317-0190.v30i4a194247

Palavras-chave:

Doença Pulmonar Obstrutiva Crônica, Biomarcadores, Fadiga Muscular, Músculo Quadríceps

Resumo

Objetivo: Comparar as respostas neuromusculares e bioquímicas do dano e fadiga muscular do quadríceps femoral entre indivíduos com doença pulmonar obstrutiva crônica (DPOC) e saudáveis. Métodos: Estudo observacional, transversal e comparativo. A amostra foi composta por 18 indivíduos alocados em dois grupos distintos: Grupo DPOC (GD) e grupo saudáveis (GS), os quais foram avaliados por meio da espirometria, do desempenho neuromuscular do quadríceps, dos marcadores bioquímicos do dano e fadiga muscular, da fatigabilidade e da dor muscular. Resultados: Observou-se diferença estatisticamente significante na potência média entre o GD e GS (99,9 ± 21,0 vs 145,1 ± 51,5, respectivamente; p= 0,02) e uma tendência das médias de pico de torque (85,7 ± 24,4 vs 104,4 ± 31,0; p= 0,45) e trabalho total (1.305,5 ± 329,9 vs 1.671,5 ± 444,5; p= 0,06) serem menores no GD que no GS, respectivamente. A concentração da LDH imediatamente após o teste isocinético foi significantemente maior no GD que no GS (402,3 ± 33,6 vs 289,4 ± 33,6, respectivamente; p= 0,03). Conclusões: O presente estudo mostrou que pacientes com DPOC tem redução da capacidade de gerar força em um determinado período de tempo quando comparado a indivíduos saudáveis. A dosagem plasmática dos marcadores bioquímicos não permitiu confirmar que os pacientes com DPOC tem maior nível de dano muscular quando realizam exercício que os controles saudáveis.

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Publicado

2023-12-31

Edição

v. 30 n. 4 (2023)

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Artigo Original

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Copyright (c) 2023 Acta Fisiátrica

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Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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Queiroz NF de, Vieira RHG, Vieira WH de B, Araujo ZT de S, Souza GF de, Nogueira IDB, et al. Comparação das respostas neuromusculares e bioquímicas entre pacientes com DPOC e indivíduos saudáveis. Acta Fisiátr. [Internet]. 31º de dezembro de 2023 [citado 1º de maio de 2024];30(4):218-24. Disponível em: https://www.revistas.usp.br/actafisiatrica/article/view/194247