Clozapine-induced hypersensitivity myocarditis presenting as sudden cardiac death

Authors

  • Natraj Katta University of Missouri School of Medicine. Department of Medicine. Division of Cardiovascular Medicine
  • Sudarshan Balla University of Missouri School of Medicine. Department of Medicine. Division of Cardiovascular Medicine
  • Kul Aggarwal University of Missouri School of Medicine. Department of Medicine. Division of Cardiovascular Medicine

DOI:

https://doi.org/10.4322/acr.2016.054

Keywords:

Clozapine, Hypersensitivity, Myocarditis, Death, Sudden, Cardiac

Abstract

Hypersensitivity myocarditis is a rare but serious adverse effect of clozapine, a commonly used psychiatric drug. We report the case of sudden cardiac death from clozapine-induced hypersensitivity myocarditis diagnosed at autopsy. A 54-year-old Caucasian male on clozapine therapy for bipolar disorder presented with a sudden onset of shortness of breath. Laboratory studies were significant for elevated N-terminal prohormone of brain natriuretic peptide. During his hospital stay, the patient died of sudden cardiac arrest from ventricular tachycardia. The autopsy revealed hypersensitivity myocarditis, which usually occurs in the first 4 weeks after the initiation of clozapine. A 4-week monitoring protocol, including laboratory assessment of troponin and C-reactive protein, may assist in the early diagnosis of this potentially fatal condition

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Published

2016-12-11

How to Cite

Katta, N., Balla, S., & Aggarwal, K. (2016). Clozapine-induced hypersensitivity myocarditis presenting as sudden cardiac death. Autopsy and Case Reports, 6(4), 9-13. https://doi.org/10.4322/acr.2016.054

Issue

Section

Article / Autopsy Case Report