Endobronchial solitary fibrous tumor

Authors

  • Cristiano Claudino Oliveira Universidade Estadual Paulista.Botucatu School of Medicine. Department of Pathology
  • Marcelo Padovani Toledo de Moraes Universidade Estadual Paulista.Botucatu School of Medicine. Department of Pathology
  • Thomas Colby Mayo Clinic. Department of Laboratory Medicine and Pathology
  • Gilmar Felisberto Oliveira Universidade Estadual Paulista. Botucatu School of Medicine. Department of Surgery and Orthopedics
  • Erica Nishida Hasimoto Universidade Estadual Paulista. Botucatu School of Medicine. Department of Surgery and Orthopedics
  • Daniele Cristina Cataneo Universidade Estadual Paulista. Botucatu School of Medicine. Department of Surgery and Orthopedics
  • Antônio José Maria Cataneo Universidade Estadual Paulista. Botucatu School of Medicine. Department of Surgery and Orthopedics
  • Julio De Faveri Universidade Estadual Paulista.Botucatu School of Medicine. Department of Pathology

DOI:

https://doi.org/10.4322/acr.2016.053

Keywords:

Solitary Fibrous Tumors, Bronchi, Immunohistochemistry, Lung Neoplasms, Pathology

Abstract

Solitary fibrous tumor (SFT) is a mesenchymal neoplasm that appears primarily in the pleura and rarely in intrapulmonary or endobronchial topography. The authors report the case of a 47-year-old woman who presented obstructive respiratory symptoms for 4 years. The chest computed tomography and bronchoscopy showed an obstructive polypoid lesion located between the trachea and the left main bronchus associated with distal atelectasis of the left lung. A resection of the lesion was performed and, macroscopically, the mass was oval, encapsulated, and firm, measuring 2.3 × 1.7 × 1.5 cm. Histology revealed low-grade mesenchymal spindle cell neoplasm, with alternating cellularity, myxoid areas, and mature adipose tissue outbreaks, as well as blood vessels with irregular walls. The immunohistochemical study was positive for CD34, CD99, and BCL2. The diagnosis was SFT in an unusual topography. The patient’s symptoms remitted after tumor excision, and no systemic problems were evident. SFTs primarily affect adults and often follow a benign course; however, their behavior is unpredictable. The presence of necrosis and mitotic activity may portend a poor prognosis. Endobronchial SFTs are rare but should be evaluated and monitored similar to SFTs at other sites, with a long-term follow-up

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Published

2016-12-11

How to Cite

Oliveira, C. C., Moraes, M. P. T. de, Colby, T., Oliveira, G. F., Hasimoto, E. N., Cataneo, D. C., Cataneo, A. J. M., & De Faveri, J. (2016). Endobronchial solitary fibrous tumor. Autopsy and Case Reports, 6(4), 35-40. https://doi.org/10.4322/acr.2016.053

Issue

Section

Article / Clinical Case Report