Pulmonary placental transmogrification associated with adenocarcinoma of the lung: a case report with a comprehensive review of the literature

Authors

  • Ameer Hamza St. John Hospital and Medical Center, Department of Pathology
  • Sidrah Khawar St. John Hospital and Medical Center, Department of Hematology & Oncology
  • Muhammad S. Khurram Vanderbilt University Medical Center, Department of Pathology
  • Ahmed Alrajjal St. John Hospital and Medical Center, Department of Pathology
  • Warda Ibrar St. John Hospital and Medical Center, Department of Pathology
  • Sajad Salehi St. John Hospital and Medical Center, Department of Pathology
  • Hong Qu St. John Hospital and Medical Center, Department of Pathology

DOI:

https://doi.org/10.4322/acr.2017.027

Keywords:

Emphysema, Hamartoma, Placenta, Solitary pulmonary nodule

Abstract

Pulmonary placental transmogrification (PT) is a rare entity with less than 40 cases reported in the literature. Most reported cases are associated with either bullous emphysema or with pulmonary fibrochondromatous hamartomas. We present only the second case of PT associated with adenocarcinoma of the lung. A 67-year-old female with multiple chronic medical ailments presented with shortness of breath and was found to have a 6-cm mass in the upper lobe of her right lung. A computed tomography (CT) guided core biopsy was performed that showed a well-differentiated adenocarcinoma. Interestingly the normal lung tissue showed placental villous architecture. A unique feature of our case is that the diagnosis was made on a needle core biopsy, unlike all the other cases in the literature. We also provide a comprehensive review of this rare entity

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Published

2017-09-30

How to Cite

Hamza, A., Khawar, S., Khurram, M. S., Alrajjal, A., Ibrar, W., Salehi, S., & Qu, H. (2017). Pulmonary placental transmogrification associated with adenocarcinoma of the lung: a case report with a comprehensive review of the literature. Autopsy and Case Reports, 7(3), 44-49. https://doi.org/10.4322/acr.2017.027

Issue

Section

Article / Clinical Case Report