Fatal disseminated cytomegalovirus infection with necrotizing oophoritis in a patient with acquired immunodeficiency syndrome

Authors

  • Laís Braga Soares Emilio Ribas Institute of Infectious Diseases.
  • Renata Buccheri Emilio Ribas Institute of Infectious Diseases.
  • Renata Bacic Palhares Emilio Ribas Institute of Infectious Diseases.
  • Amaro Nunes Duarte-Neto Universidade de São Paulo, Faculty of Medicine, Department of Anatomic Pathology, Emergency Department and LIM06.

DOI:

https://doi.org/10.4322/acr.2018.029

Keywords:

Cytomegalovirus; Acquired Immunodeficiency Syndrome; Oophoritis; Autopsy

Abstract

Disseminated human cytomegalovirus (CMV) disease occurs mainly as a congenital infection and among immunocompromised hosts. Patients with acquired immunodeficiency syndrome (AIDS) are at increased risk for CMV infection, and the most prevalent clinical manifestation is retinitis, followed by colitis, esophagitis, pneumonitis, and encephalitis. CMV oophoritis is poorly described in the literature with some cases reported in patients with hematological or solid malignancies, bone marrow or solid organ transplantation, immunosuppressive therapy, and advanced AIDS cases. We report the case of a 61-year-old woman with a recent diagnosis of AIDS, which was associated with a wasting syndrome. The patient presented with abdominal pain, headache, cutaneous vesicular lesions on the abdomen, anemia, lymphopenia, and hyponatremia; she died suddenly on the fourth day of hospitalization. The autopsy was performed and demonstrated disseminated CMV infection with hemorrhagic encephalitis as the immediate cause of death. Additionally, pneumonitis, extensive adrenalitis, ulcerated enteritis, focal hepatitis, and necrotizing oophoritis were found.

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Published

2018-08-31

How to Cite

Soares, L. B., Buccheri, R., Palhares, R. B., & Duarte-Neto, A. N. (2018). Fatal disseminated cytomegalovirus infection with necrotizing oophoritis in a patient with acquired immunodeficiency syndrome. Autopsy and Case Reports, 8(3), e2018029. https://doi.org/10.4322/acr.2018.029

Issue

Section

Article / Autopsy Case Report