Juvenile-onset recurrent respiratory papillomatosis with pulmonary involvement and carcinomatous transformation

Authors

  • Gabriel Lorente Mitsumoto Santa Casa de São Paulo School of Medical Sciences, School of Medicine.
  • Fabiola Del Carlo Bernardi Santa Casa de São Paulo School of Medical Sciences, School of Medicine.
  • Juliana Fracalossi Paes Santa Casa de São Paulo School of Medical Sciences, School of Medicine.
  • Luisa Lina Villa Universidade de São Paulo, Faculty of Medicine, Department of Radiology and Oncology.
  • Barbara Mello Universidade de São Paulo, Faculty of Medicine, Department of Radiology and Oncology.
  • Geanete Pozzan Santa Casa de São Paulo School of Medical Sciences, School of Medicine.

DOI:

https://doi.org/10.4322/acr.2018.035

Keywords:

Carcinoma, Squamous Cell; Human Papillomavirus 11; Lung Neoplasms; Papillomavirus Infections; Recurrent Respiratory Papillomatosis

Abstract

Papilloma associated with recurrent respiratory papillomatosis (RRP), caused by human papilloma virus (HPV) infection types 6 and 11, is the most common benign neoplasm of the larynx. The clinical features of RRP vary widely from mild to aggressive forms. RRP in children is known as juvenile-onset recurrent respiratory papillomatosis (JORRP). Its outcome may be poor or even fatal due to the high rate of recurrence and eventual spread to the entire respiratory tract. Pulmonary invasion is reported to occur in 3.3% of patients with RRP, and malignant transformation in 0.5% of patients. We report the case of a 39-year-old female patient with a diagnosis of JORRP from the age of 3 years, with extensive bilateral pulmonary involvement and malignant transformation. Analysis of the papilloma and carcinomatous tissues revealed the presence of HPV type 11, which is associated with rapid and aggressive progression. We discussed the case on the basis of a literature review on pulmonary invasion, malignant transformation, and HPV 11 aggressiveness.

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Author Biographies

Fabiola Del Carlo Bernardi, Santa Casa de São Paulo School of Medical Sciences, School of Medicine.

Irmandade da Santa Casa de Misericórdia de São Paulo, Department of Pathologic Sciences.

Luisa Lina Villa, Universidade de São Paulo, Faculty of Medicine, Department of Radiology and Oncology.

Instituto do Câncer do Estado de São Paulo.

Barbara Mello, Universidade de São Paulo, Faculty of Medicine, Department of Radiology and Oncology.

Instituto do Câncer do Estado de São Paulo.

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Published

2018-08-31

How to Cite

Mitsumoto, G. L., Bernardi, F. D. C., Paes, J. F., Villa, L. L., Mello, B., & Pozzan, G. (2018). Juvenile-onset recurrent respiratory papillomatosis with pulmonary involvement and carcinomatous transformation. Autopsy and Case Reports, 8(3), e2018035. https://doi.org/10.4322/acr.2018.035

Issue

Section

Article / Autopsy Case Report