Ameloblastoma with distinctive granular cell pattern

an 8 case study


  • Ana Maria Hoyos Cadavid Universidade de São Paulo, School of Dentistry
  • Tathyane Harumi Nakajima Teshima Universidade de São Paulo, School of Dentistry
  • Clóvis Antônio Lopes Pinto AC Camargo Cancer Center
  • Cláudia Malheiros Coutinho Camillo AC Camargo Cancer Center
  • Silvia Vanessa Lourenço


Ameloblastoma, Odontogenic Tumors, Neoplasms


Ameloblastoma with granular cell pattern (AGC) is classified as an unusual histological subtype of solid/multicystic ameloblastoma, characterized by granular changes in stellate-like cells located within the inner portion of the epithelial follicles. Studies have revealed that lysosomal overload causes cytoplasmic granularity; however, the mechanism involved remains poorly understood. Here we report on eight cases of granular cell ameloblastoma, in the posterior region of the mandible. The age of the patients included in this case series ranged from 35 -64 years old and 87.5% of cases occurred in non-Caucasians, with a slight gender predilection for men (62.5%). There was no evidence of recurrence, and the majority of the cases were treated with surgical resection (87.5%). All tumors displayed histopathological features consistent with the diagnosis of ameloblastoma with granular cell pattern.


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How to Cite

Cadavid, A. M. H., Teshima, T. H. N., Pinto, C. A. L., Camillo, C. M. C., & Lourenço, S. V. (2018). Ameloblastoma with distinctive granular cell pattern: an 8 case study. Autopsy and Case Reports, 8(4), e2018052. Retrieved from



Article / Clinical Case Report