ALK+ Anaplastic large cell lymphoma with extensive cardiac involvement: A rare case report and review of the literature

Authors

DOI:

https://doi.org/10.4322/acr.2020.231

Keywords:

Lymphoma, Large-cell, Anaplastic, Anaplastic lymphoma kinase, Heart, Thymus Gland, Thromboembolism

Abstract

Cardiac lymphoma is a rare entity. In this setting, the secondary involvement of the heart is far more frequent than the primary cardiac lymphoma. Herein, we present an autopsy case of a disseminated anaplastic lymphoma kinase (ALK)- positive anaplastic large cell lymphoma with a dominant mediastinal involvement. Extensive cardiac infiltration with the near replacement of the myocardial wall by the neoplastic cells was observed. A total of nine isolated case reports of anaplastic large cell lymphoma with cardiac involvement were found in the English-language literature, and a widespread cardiac and thymic infiltration by the systemic ALK-positive anaplastic large cell lymphoma has not been documented. An incidental regenerative nodule was also identified in the liver. The patient died of pulmonary thromboembolism and cardiac arrest.

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Published

2021-01-28

How to Cite

Nambiyar, K., Gupta, . K., Debi, U., Sinha, S. K., & Kochhar, R. (2021). ALK+ Anaplastic large cell lymphoma with extensive cardiac involvement: A rare case report and review of the literature. Autopsy and Case Reports, 11, e2020231. https://doi.org/10.4322/acr.2020.231

Issue

Section

Autopsy Case Report and Review