Gestational gigantomastia with fatal outcome

Authors

  • Natalia Rakislova Barcelona Institute for Global health (ISGlobal), Hospital Clínic- Universitat de Barcelona, Barcelona, Spain and Universitat de Barcelona, Hospital Clinic, Department of Pathology, Barcelona, Spain https://orcid.org/0000-0001-5030-3526
  • Lucilia Lovane Maputo Central Hospital, Department of Pathology, Maputo, Mozambique https://orcid.org/0000-0002-0218-6190
  • Fabiola Fernandes Maputo Central Hospital, Department of Pathology, Maputo, Mozambique and Eduardo Mondlane University, Faculty of Medicine, Department of Pathology, Maputo, Mozambique https://orcid.org/0000-0001-9095-7743
  • Emília Gonçalves Eduardo Mondlane University, Faculty of Medicine, Department of Ginecology and Obstetrics, Maputo, Mozambique and Maputo Central Hospital, Department of Ginecology and Obstetrics, Maputo, Mozambique https://orcid.org/0000-0001-7565-877X
  • Quique Bassat Barcelona Institute for Global health (ISGlobal), Hospital Clínic- Universitat de Barcelona, Barcelona, Spain and Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique and Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain and University of Barcelona, Hospital Sant Joan de Déu, Pediatrics Department, Pediatric Infectious Diseases Unit, Barcelona, Spain and Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain https://orcid.org/0000-0003-0875-7596
  • Sibone Mocumbi Eduardo Mondlane University, Faculty of Medicine, Department of Ginecology and Obstetrics, Maputo, Mozambique and Maputo Central Hospital, Department of Ginecology and Obstetrics, Maputo, Mozambique https://orcid.org/0000-0002-2475-2560
  • Jaume Ordi Barcelona Institute for Global health (ISGlobal), Hospital Clínic- Universitat de Barcelona, Barcelona, Spain and Universitat de Barcelona, Hospital Clinic, Department of Pathology, Barcelona, Spain https://orcid.org/0000-0002-4820-7954
  • Carla Carrilho Maputo Central Hospital, Department of Pathology, Maputo, Mozambique and Eduardo Mondlane University, Faculty of Medicine, Department of Pathology, Maputo, Mozambique https://orcid.org/0000-0003-0208-7309

DOI:

https://doi.org/10.4322/acr.2020.213

Keywords:

Gigantomastia, Breast Diseases, Pregnancy, Pregnancy Complications, HIV

Abstract

Gigantomastia is a rare disease defined by an extreme and rapid enlargement of the breast, generally bilateral. The majority of cases are reported in pregnant women. Ninety-eight cases of gestational gigantomastia have been identified in electronic databases, and those with fatal outcomes comprised only 2 cases (2%). Despite its benign nature, it can lead to severe complications and even death. Its etiology has not been fully elucidated, but it has been speculated that a hormonal component may play a role in the pathogenesis. Currently, treatment options are limited, and surgery is gaining importance, but it is often not feasible in low-resource settings. Herein, we describe a case of a 30-year-old HIVpositive female with no relevant past medical history, who died due to the complications of gestational gigantomastia at the Maputo Central Hospital, in Mozambique.

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Published

2020-08-24

How to Cite

Rakislova, N. ., Lovane, L. ., Fernandes, F. ., Gonçalves, E. ., Bassat, Q. ., Mocumbi, S. ., Ordi, J. ., & Carrilho, . C. . (2020). Gestational gigantomastia with fatal outcome. Autopsy and Case Reports, 10(4), e2020213. https://doi.org/10.4322/acr.2020.213

Issue

Section

Autopsy Case Report and Review