Primary malignant giant cell tumor of the sternum

Mohammed  Imaduddin; Pavithra  Ayyanar; Mahesh  Sultania; Dillip  Muduly; Mukund  Namdev Sable; Suprava  Naik; Sambit  Mohanty; Madhabananda  Kar

doi:10.4322/acr.2021.281

Authors

Mohammed Imaduddin All India Institute of Medical Sciences, Department of Surgical Oncology, Sijua, Patrapada, Bhubaneswar, Odisha, India https://orcid.org/0000-0001-8398-8840
Pavithra Ayyanar All India Institute of Medical Sciences, Department of Pathology and Lab Medicine, Sijua, Patrapada, Bhubaneswar, Odisha, India https://orcid.org/0000-0002-4233-6835
Mahesh Sultania All India Institute of Medical Sciences, Department of Surgical Oncology, Sijua, Patrapada, Bhubaneswar, Odisha, India 2 All India Institute of Medical Sciences, Department of Pathology and Lab Medicine, Sijua, Patrapada, Bhubaneswar, Odish https://orcid.org/0000-0003-1008-8694
Dillip Muduly All India Institute of Medical Sciences, Department of Surgical Oncology, Sijua, Patrapada, Bhubaneswar, Odisha, India https://orcid.org/0000-0001-6427-5714
Mukund Namdev Sable All India Institute of Medical Sciences, Department of Pathology and Lab Medicine, Sijua, Patrapada, Bhubaneswar, Odisha, India https://orcid.org/0000-0003-1547-8595
Suprava Naik All India Institute of Medical Sciences, Department of Radiodiagnosis, Sijua, Patrapada, Bhubaneswar, Odisha, India https://orcid.org/0000-0002-0793-9702
Sambit Mohanty Prolife Diagnostics, Department of Pathology, Sijua, Patrapada, Bhubaneswar, Odisha, India https://orcid.org/0000-0001-5094-2424
Madhabananda Kar All India Institute of Medical Sciences, Department of Surgical Oncology, Sijua, Patrapada, Bhubaneswar, Odisha, India https://orcid.org/0000-0003-1690-4058

DOI:

https://doi.org/10.4322/acr.2021.281

Keywords:

Neoplasms, Giant cell tumors, Sternum

Abstract

Primary malignant giant cell tumor (PMGCT) is a diagnosis based on the presence of a high-grade sarcomatous component along with a typical benign giant cell tumor (GCT). We report the first case of PMGCT of the sternum in a 28-year-old male with painless swelling over the manubrium sterni. The differential diagnoses of PMGCT and giant cell-rich osteosarcoma were considered. Surgical resection was performed, and the reconstruction was done with a neosternum using polymethyl methacrylate and prolene mesh. At 30 months follow-up, the patient is disease-free.

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Primary malignant giant cell tumor of the sternum

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