Renal angiomyolipoma with epithelial cyst
DOI:
https://doi.org/10.4322/acr.2021.308Keywords:
Angiomyolipoma, Neoplasms, Kidney, Nephrectomy, Diagnosis, DifferentialAbstract
Angiomyolipoma with epithelial cysts (AMLEC) is a recently described entity and is an uncommon subtype of kidney angiomyolipomas. AMLEC is a benign entity but usually masquerades a renal cell carcinoma on imaging examination. AMLEC has a distinct histological and immunohistochemical staining pattern, which helps in the pathological diagnosis. We present a rare case of AMLEC in a 26-year-old female, which was provisionally diagnosed as renal cell carcinoma on radiology. We also summarize the differential diagnosis of this rare variant, its characteristic features, and a review of the literature.
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L’Hostis H, Deminiere C, Ferriere JM, Coindre JM. Renal angiomyolipoma: a clinicopathologic, immunohistochemical, and follow-up study of 46 cases. Am J Surg Pathol. 1999;23(9):1011-20. http://dx.doi.org/10.1097/00000478-199909000-00003. PMid:10478660.
Cheng L, Gu J, Eble JN, et al. Molecular genetic evidence for different clonal origin of components of human renal angiomyolipomas. Am J Surg Pathol. 2001;25(10):1231-6. http://dx.doi.org/10.1097/00000478-200110000-00002. PMid:11688456.
Fine SW, Reuter VE, Epstein JI, Argani P. Angiomyolipoma with epithelial cysts (AMLEC): a distinct cystic variant of angiomyolipoma. Am J Surg Pathol. 2006;30(5):593-9. http://dx.doi.org/10.1097/01.pas.0000194298.19839.b4. PMid:16699313.
Davis CJ, Barton JH, Sesterhenn IA. Cystic angiomyolipoma of the kidney: a clinicopathologic description of 11 cases. Mod Pathol. 2006;19(5):669-74. http://dx.doi.org/10.1038/modpathol.3800572. PMid:16528375.
Srigley JR, Delahunt B, Eble JN, et al. The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. Am J Surg Pathol. 2013;37(10):1469-89. http://dx.doi.org/10.1097/PAS.0b013e318299f2d1. PMid:24025519.
Zhou M, Kort E, Hoekstra P, et al. Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney are the same disease entity: molecular and histologic evidence. Am J Surg Pathol. 2009;33(1):72-80. http://dx.doi.org/10.1097/PAS.0b013e3181852105. PMid:18971776.
Martignoni G, Bonetti F, Chilosi M, et al. Cathepsin K expression in the spectrum of perivascular epithelioid cell (PEC) lesions of the kidney. Mod Pathol. 2012;25(1):100-11. http://dx.doi.org/10.1038/modpathol.2011.136. PMid:21874011.
Karafin M, Parwani AV, Netto GJ, et al. Diffuse expression of PAX2 and PAX8 in the cystic epithelium of mixed epithelial stromal tumor, angiomyolipoma with epithelial cysts, and primary renal synovial sarcoma: evidence supporting renal tubular differentiation. Am J Surg Pathol. 2011;35(9):1264-73. http://dx.doi.org/10.1097/PAS.0b013e31822539a1. PMid:21836481.
Pereira JE Fo, Amorim DM, Sweet GM, Freitas LAR, Athanazio PR, Athanazio DA. Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of Melan A and HMB45 positivity in the cystic epithelial lining. Ann Diagn Pathol. 2012;16(5):397-401. http://dx.doi.org/10.1016/j.anndiagpath.2011.03.004. PMid:21676635.
Armah HB, Yin M, Rao UN, Parwani AV. Angiomyolipoma with epithelial cysts (AMLEC): a rare but distinct variant of angiomyolipoma. Diagn Pathol. 2007;2(1):11. http://dx.doi.org/10.1186/1746-1596-2-11. PMid:17376246.
Mikami S, Oya M, Mukai M. Angiomyolipoma with epithelial cysts of the kidney in a man. Pathol Int. 2008;58(10):664-7. http://dx.doi.org/10.1111/j.1440-1827.2008.02287.x. PMid:18801088.
Rosenkrantz AB, Hecht EM, Taneja SS, Melamed J. Angiomyolipoma with epithelial cysts: mimic of renal cell carcinoma. Clin Imaging. 2010;34(1):65-8. http://dx.doi.org/10.1016/j.clinimag.2009.04.026. PMid:20122523.
Yeo DM, Chung DJ, Kim TJ, Lee IK, Hahn ST, Lee JMCT. CT and MRI findings of angiomyolipoma with epithelial cysts of the kidney: a case report. J Korean Soc Radiol. 2010;63(2):173-6. http://dx.doi.org/10.3348/jksr.2010.63.2.173.
Wei J, Li Y, Wen Y, Li L, Zhang R. Renal angiomyolipoma with epithelial cysts: a rare entity and review of literature. Int J Clin Exp Pathol. 2015;8(9):11760-5. PMid:26617923.
Wood A, Young F, O’Donnell M. Angiomyolipoma with epithelial cysts masquerading as a cystic renal cell carcinoma. Curr Urol. 2017;9(4):209-11. http://dx.doi.org/10.1159/000447142. PMid:28413382.
Gorin MA, Rowe SP, Allaf ME, Argani P. Angiomyolipoma with epithelial cysts: add one to the differential of cystic renal lesions. Int J Urol. 2015;22(11):1081-2. http://dx.doi.org/10.1111/iju.12908. PMid:26303457.
Wan L, Zhang Q, Hu P-Y, Zhao M. Renal angiomyolipoma with epithelial cysts: report of a rare cystic variant of angiomyolipoma and review of the literature. Int J Clin Exp Pathol. 2016;9(2):2599-605.
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