Cardiac amyloidosis: a challenging diagnosis

Authors

  • Graziele Cristina Palancio Morais Department of Pathological Sciences – Faculdade de Ciências Médicas – Santa Casa de Misericórdia de São Paulo - São Paulo/SP
  • Marjorie Moreira Arruda Department of Pathological Sciences – Faculdade de Ciências Médicas – Santa Casa de Misericórdia de São Paulo - São Paulo/SP
  • José Carlos de Aguiar Bonadia Department of Pathological Sciences – Faculdade de Ciências Médicas – Santa Casa de Misericórdia de São Paulo - São Paulo/SP
  • Geanete Pozzan Department of Pathological Sciences – Faculdade de Ciências Médicas – Santa Casa de Misericórdia de São Paulo - São Paulo/SP

DOI:

https://doi.org/10.4322/acr.%25y.98461

Keywords:

Amyloidosis, Cardiomyopathy, Restrictive, Autopsy

Abstract

Cardiovascular involvement of amyloidosis is present in 90% of cases, which is frequently associated with the primary form of the disease (AL amyloidosis). Clinical manifestations are represented by heart failure due to restrictive myocardiopathy and electrical impulse conduction abnormalities, which are clinically remarkable in up to 50% of the cases. The prognosis of patients with systemic amyloidosis is directly associated with the presence of cardiac involvement, such that survival does not usually exceed 4 months after the onset of heart failure signs and symptoms. The authors report a case of primary systemic amyloidosis, diagnosed only at autopsy, with severe cardiac involvement.

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Published

2014-12-22

How to Cite

Morais, G. C. P., Arruda, M. M., Bonadia, J. C. de A., & Pozzan, G. (2014). Cardiac amyloidosis: a challenging diagnosis. Autopsy and Case Reports, 4(4), 9-17. https://doi.org/10.4322/acr.%y.98461

Issue

Section

Article / Autopsy Case Report