Plasmacytoid urothelial carcinoma: a case of histological variant of urinary bladder cancer with aggressive behavior

Authors

  • Leonardo Gomes da Fonseca Department of Clinical Oncology - Instituto do Câncer do Estado de São Paulo, São Paulo/SP
  • Ciro Eduardo Souza Department of Clinical Oncology - Instituto do Câncer do Estado de São Paulo, São Paulo/SP
  • Romulo Loss Mattedi Department of Pathology - Instituto do Câncer do Estado de São Paulo, São Paulo/SP
  • Daniel Motta Girardi Department of Clinical Oncology - Instituto do Câncer do Estado de São Paulo, São Paulo/SP
  • Álvaro Sadek Sarkis Department of Urology - Instituto do Câncer do Estado de São Paulo, São Paulo/SP
  • Paulo Marcelo Gem Hoff Department of Urology - Instituto do Câncer do Estado de São Paulo, São Paulo/SP

DOI:

https://doi.org/10.4322/acr.%25y.98467

Keywords:

Carcinoma, Urothelium, Urinary Bladder Neoplasms, Cystectomy

Abstract

Plasmocytoid variant urothelial carcinoma (PVUC) of the urinary bladder is a rare histological variant of transitional cell carcinoma. Data regarding PVUC shows that this neoplasia presents a distinctive clinical outcome represented by aggressive behavior and poor survival rate. The authors report a case of a 57-year-old male patient with a 3-month history of hematuria and pelvic pain. Radical cystectomy with lymphadenectomy was performed and pathological examination showed a pT3pN0 PVUC of the bladder. The patient remained free of recurrence for 8 months, but the disease recurred involving the abdominal wall and subcutaneous tissue. Chemotherapy provided a positive clinical response and relief of symptoms. The authors call attention to the aggressiveness of this rare variant of bladder cancer and recommend radical surgery and multidisciplinary management of this neoplasm.

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Published

2014-12-22

How to Cite

Fonseca, L. G. da, Souza, C. E., Mattedi, R. L., Girardi, D. M., Sarkis, Álvaro S., & Hoff, P. M. G. (2014). Plasmacytoid urothelial carcinoma: a case of histological variant of urinary bladder cancer with aggressive behavior. Autopsy and Case Reports, 4(4), 57-61. https://doi.org/10.4322/acr.%y.98467

Issue

Section

Article / Clinical Case Report