Unmasking histoplasmosis immune reconstitution inflammatory syndrome in a patient recently started on antiretroviral therapy

Authors

  • Reuben Kiggundu Makerere University. Infectious Disease Institute. College of Health Sciences
  • Henry W. Nabeta Makerere University. School of Medicine. College of Health Sciences
  • Richard Okia Makerere University. School of Medicine. College of Health Sciences
  • Joshua Rhein Makerere University. Infectious Disease Institute. College of Health Sciences University of Minnesota. Department of Medicine
  • Robert Lukande Makerere University. School of Biomedical Sciences. College of Health Sciences

DOI:

https://doi.org/10.4322/acr.2016.048

Keywords:

Histoplasmosis, Immune Reconstitution Inflammatory Syndrome, Antiretroviral Therapy, Highly Active, Fluconazole

Abstract

Histoplasmosis is the most common endemic mycoses among HIV-infected people. Patients with suppressed cell immunity mainly due to HIV are at increased risk of disseminated disease. Dermatological manifestations of immune reconstitution inflammatory syndrome (IRIS) and cutaneous manifestations of histoplasmosis similar to an IRIS event have been previously described. We report the case of a 43-year-old male who presented with cutaneous disseminated histoplasmosis due to Histoplasma capsulatum var. capsulatum 4 months after the onset of the antiretroviral therapy and some improvement in the immune reconstitution. After 2 weeks of amphotericin B and itraconazole therapy, the scheduled treatment involved fluconazole maintenance therapy, which resulted in an improvement of his skin lesions

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Published

2016-12-11

Issue

Vol. 6 No. 4 (2016)

Section

Article / Clinical Case Report

License

Authors of articles published by Autopsy and Case Report retain the copyright of their work without restrictions, licensing it under the Creative Commons Attribution License - CC-BY, which allows articles to be re-used and re-distributed without restriction, as long as the original work is correctly cited.

How to Cite

Kiggundu, R., Nabeta, H. W., Okia, R., Rhein, J., & Lukande, R. (2016). Unmasking histoplasmosis immune reconstitution inflammatory syndrome in a patient recently started on antiretroviral therapy. Autopsy and Case Reports, 6(4), 27-33. https://doi.org/10.4322/acr.2016.048