Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate

Authors

  • Xiaoping Zhan Shanghai Jiaotong University; School of Pharmacy
  • Zhenmin Mao Shanghai Jiaotong University; School of Pharmacy
  • Sijing Chen Shanghai Jiaotong University; School of Pharmacy
  • Shaoxiong Chen Strategic Alliance of Biomedical Technology
  • Liqun Wang Strategic Alliance of Biomedical Technology

DOI:

https://doi.org/10.1590/S1984-82502015000200015

Abstract

The purpose of this study was to develop a reservoir-type transdermal delivery system for isosorbide dinitrate (ISDN). The developed patch consisted of five layers from bottom to top, namely, a temporary liner, an adhesive layer, a rate-controlling membrane, a reservoir and a backing. The effects of chemical penetration enhancers, reservoir materials and rate-controlling membranes on the release behaviour of ISDN from the transdermal patch were studied, and the; in vitro; release of ISDN from the developed patch was studied and compared with the commercially available ISDN patch. The results showed that there was no significant difference in permeation rates between the developed reservoir-type patch and the commercially available ISDN patch (;p;>; 0.05). Moreover, the cumulative release ratio of the commercially available ISDN patch in 48 h was up to 89.8%, whereas the developed patch was only 34.9%, which meant the sustained release time of the developed patch was much longer than the commercially available ISDN patch, and would promote the satisfaction of the patient.

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Published

2015-06-01

How to Cite

Zhan, X., Mao, Z., Chen, S., Chen, S., & Wang, L. (2015). Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate. Brazilian Journal of Pharmaceutical Sciences, 51(2), 373-382. https://doi.org/10.1590/S1984-82502015000200015

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Articles