Wound-healing evaluation of ointment from Stryphnodendron adstringens (barbatimão) in rat skin

Authors

  • Luzmarina Hernandes University of Maringá; Morphophysiological Sciences Department
  • Luciene Marques da Silva Pereira University of Maringá; Morphophysiological Sciences Department
  • Fabiana Palazzo University of Maringá; Morphophysiological Sciences Department
  • João Carlos Palazzo de Mello University of Maringá; Pharmacy Department

DOI:

https://doi.org/10.1590/S1984-82502010000300005

Keywords:

Stryphnodendron adstringens^i1^spharmacogn, Stryphnodendron adstringens^i1^scicatrizant eff, "Barbatimão"^i1^spharmacogn, Wound^i1^sheal, Wound^i1^sexperimental st, Reepithelialization

Abstract

This study evaluated the cicatrizant effect of an ointment containing 1% of the ethyl-acetate fraction extracted from the stem bark of "barbatimão" (Stryphnodendron adstringens), in wounds made in the skin of rats, after 4, 7 and 10 days of treatment. Control wounds were treated with a base ointment without extract. The proliferation of keratinocytes in the area of reepithelialization was evaluated by counting the number of epithelial cells that were blocked in metaphase by vincristine sulfate. The length of the reepithelialized margin and the contraction of the wound were measured. Topical application of the "barbatimão" ointment stimulated proliferation of the keratinocytes, but had no effect on the length of the epithelium or on the contraction of the wounds.

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Published

2010-09-01

Issue

Vol. 46 No. 3 (2010)

Section

Original Papers

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

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How to Cite

Wound-healing evaluation of ointment from Stryphnodendron adstringens (barbatimão) in rat skin . (2010). Brazilian Journal of Pharmaceutical Sciences, 46(3), 431-436. https://doi.org/10.1590/S1984-82502010000300005