Antidiabetic and antihyperlipidemic effects of Dillenia indica (L.) leaves extract

Authors

  • Sunil Kumar Kurukshetra University; Institute of Pharmaceutical Sciences
  • Vipin Kumar Kurukshetra University; Institute of Pharmaceutical Sciences
  • Om Prakash Kurukshetra University; Institute of Pharmaceutical Sciences

DOI:

https://doi.org/10.1590/S1984-82502011000200018

Keywords:

Dillenia indica^i1^santidiabetic effe, Dillenia indica^i1^sexperimental st, Dillenia indica^i1^santihyperlipidemic effe, Antidiabetics^i1^sexperimental st, Serum transaminase, Serum cholesterol, HDL-cholesterol level

Abstract

The present study was carried out to evaluate antidiabetic and antihyperlipidemic effects of Dillenia indica methanolic leaves extracts in streptozotocin induced diabetic Wistar rats by administering graded oral doses (250 and 500 mg/kg body weight) for 21 days. The extract showed significant antidiabetic activity (p<0.001). Furthermore, the decreased body weight of rats was significantly improved after extract treatments. Daily oral treatment with the extract for 21 days to diabetic rats, also resulted in significant reduction in serum cholesterol, triglycerides and serum transaminase levels but HDL-cholesterol level was found to be improved (p<0.001) as compared to the diabetic control group. The extract treatment also showed to enhance serum insulin level in diabetic rats as compared to the diabetic control group. In conclusion, D. indica leaf extract might be useful for diabetes mellitus management and other abnormalities associated with this metabolic disorder.

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Published

2011-06-01

Issue

Section

Articles

How to Cite

Antidiabetic and antihyperlipidemic effects of Dillenia indica (L.) leaves extract . (2011). Brazilian Journal of Pharmaceutical Sciences, 47(2), 373-378. https://doi.org/10.1590/S1984-82502011000200018