Formulation of a modified release metformin. HCl matrix tablet: influence of some hydrophilic polymers on release rate and in-vitro evaluation
DOI:
https://doi.org/10.1590/S1984-82502011000300006Keywords:
Metformin^i1^srelease prof, Metformin.HCl^i1^smodified rele, Metformin.HCl^i1^sin-vitro evaluat, Hydrophilic polymers^i1^sinflue, Hydrophilic polymers^i1^sdrugs rele, Korsmeyer-Peppas model^i1^sdissolution profiAbstract
Metformin hydrochloride is an antidiabetic agent which improves glucose tolerance in patients with type 2 diabetes and reduces basal plasma levels of glucose. In this study, a simplex centroid experimental design with 69 runs was used to select the best combination of some hydrophilic polymers that rendered a 24 h in-vitro release profile of metformin.HCl. The Korsmeyer-Peppas model was used to model the dissolution profiles since it presented the best fit to the experimental data. Further, a cubic model predicted the best formulation of metformin.HCl containing polyvinyl pyrrolidone, ethyl cellulose, hydroxypropyl methyl cellulose, carrageenan, sodium alginate, and gum arabic at 6.26, 68.7, 6.26, 6.26, 6.26 and 6.26 % levels, respectively. The validation runs confirmed the accuracy of the cubic model with six components for predicting the best set of components which rendered a once-a-day modified release hydrophilic matrix tablet in compliance with the USP specifications.Downloads
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Published
2011-09-01
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Formulation of a modified release metformin. HCl matrix tablet: influence of some hydrophilic polymers on release rate and in-vitro evaluation . (2011). Brazilian Journal of Pharmaceutical Sciences, 47(3), 483-493. https://doi.org/10.1590/S1984-82502011000300006