Design and preparation of a novel colon-targeted tablet of hydrocortisone

Authors

  • Yachao Ren Harbin Medical University-Daqing
  • Lei Jiang Harbin Medical University-Daqing
  • Shuman Yang University of Cincinnati Medical Center; Department of Environmental Health; Division of Epidemiology and Biostatistics
  • Sainan Gao Harbin Medical University-Daqing
  • Hui Yu Harbin Medical University-Daqing
  • Jie Hu Harbin Medical University-Daqing
  • Dandan Hu Harbin Medical University-Daqing
  • Wenbin Mao Heilongjiang Bayi Agricultural University; College of Animal Science and Technology
  • Haisheng Peng Harbin Medical University-Daqing
  • Yulong Zhou Heilongjiang Bayi Agricultural University; College of Animal Science and Technology

DOI:

https://doi.org/10.1590/S1984-82502016000200002

Abstract

The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation degree, Fourier transform infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning electron microscope (SEM) investigations showed that the composite film was formed when chitosan and gelatin were jointly reacted jointly. The results showed that a 6:4 blend ratio was the optimal chitosan/gelatin blend ratio. In vitro drug release results indicated that the Eudragit- and chitosan/gelatin-bilayer coating system prevented drug release in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF). However, the drug release from a bilayer-coated tablet in SCF increased over time, and the drug was almost completely released after 24 h. Overall, colon-targeted drug delivery was achieved by using a chitosan/gelatin complex film and a multilayer coating system.

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Published

2016-06-01

Issue

Section

Articles

How to Cite

Design and preparation of a novel colon-targeted tablet of hydrocortisone . (2016). Brazilian Journal of Pharmaceutical Sciences, 52(2), 239-250. https://doi.org/10.1590/S1984-82502016000200002