Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion

Authors

  • Akram Torki Shahrekord University; Faculty of Science; Department of Biology
  • Valiallah Khalaji-Pirbalouty Shahrekord University; Faculty of Science; Department of Biology
  • Zahra Lorigooini Shahrekord University of Medical Sciences; Basic Health Sciences Institute; Medicinal Plants Research Center
  • Mahmoud Rafieian-Kopaei Shahrekord University of Medical Sciences; Basic Health Sciences Institute; Medicinal Plants Research Center
  • Arezo Sadeghimanesh Shahrekord University; Faculty of Science; Department of Biology
  • Zahra Rabiei Shahrekord University of Medical Sciences; Basic Health Sciences Institute; Medicinal Plants Research Center

DOI:

https://doi.org/10.1590/s2175-97902018000117251

Keywords:

Boraginaceae/phytochemistry, Brain ischemia, Spatial memory/drug effects, Malondialdehyde/pharmacology, Neuroprotection/drug effects, Lipidic peroxidation/drug effects, Antioxidant capacity, Passive avoidance memory.

Abstract

Stroke is the third leading cause of mortality and disability in industrial countries. Treatment with herbs with antioxidant properties has been reported to be an alternative to the conventional treatments. This study was conducted to investigate the effect of Anchusa italica extract on hippocampal injury induced by transient global cerebral ischemia and reperfusion in the rat. To do so, 50 rats were randomly assigned to five groups; control, sham, ischemia, and 50 or 100 mg/kg of Anchusa italica treated animals. Ischemia was induced by occlusion of carotid artery for 30 minutes. Afterward, behavioral tests and biochemical analyses were conducted. Induction of ischemia/reperfusion caused a decline in learning and passive avoidance memory in rats. Moreover, Anchusa italica caused an increase in learning and improved the passive avoidance memory. Induction of ischemia/reperfusion caused a decrease in the antioxidant capacity of the brain and serum as well as an increase in the malondialdehyde of the brain and serum. Anchusa italica led to an increase in the antioxidant capacity of the brain and serum and decrease in the malondialdehyde of the brain and serum. Overall, because of its protective effects on spatial memory, passive avoidance learning, antioxidant capacity, and lipid peroxidation during ischemia/reperfusion, Anchusa italica might be beneficial in ischemic patients.

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Published

2018-06-07

Issue

Section

Articles

How to Cite

Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion. (2018). Brazilian Journal of Pharmaceutical Sciences, 54(1), e17251. https://doi.org/10.1590/s2175-97902018000117251