A pH-responsive drug delivery matrix from an interpolyelectrolyte complex

preparation and pharmacotechnical properties

Authors

  • Jorge Andrés Montaña Universidad Nacional de Colombia, Sede Bogotá, Facultad de Ciencias, Departamento de Farmacia
  • León Darío Perez Universidad Nacional de Colombia, Sede Bogotá, Facultad de Ciencias, Departamento de Química
  • Yolima Baena Universidad Nacional de Colombia, Sede Bogotá, Facultad de Ciencias, Departamento de Farmacia

DOI:

https://doi.org/10.1590/s2175-9790201800021718

Keywords:

Interpolyelectrolyte complex, Pharmacotechnical properties, Dexibuprofen, Controlled release, Hydrophillic matrix

Abstract

Interpolyelectrolyte complexes, which constitute a type of polymeric material obtained through the selfassembly of oppositely charged polymers, exhibit interesting properties for use in the design of smart matrices for drug delivery. In the present study, a stoichiometric interpolyelectrolyte complex (SIPEC) composed of Eudragit E® and Eudragit® L100 was obtained at pH 6.0 and characterized and evaluated as a hydrophilic matrix for dexibuprofen. The formation of a SIPEC was monitored by ζ-potential measurements and characterized using infrared spectroscopy, thermal analysis, and scanning electron microscopy. The results indicated that a SIPEC obtained under these conditions can be used as a matrix for controlling the release of dexibuprofen and exhibit a pH-triggered release.

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Published

2018-07-26

Issue

Vol. 54 No. 2 (2018)

Section

Articles

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on line journal has open and free access.

How to Cite

A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties. (2018). Brazilian Journal of Pharmaceutical Sciences, 54(2), e17183. https://doi.org/10.1590/s2175-9790201800021718