The traditional Chinese medicine formulation Ruanjian Sanjie Decoction regulates the tumor matrix and improves the anti-tumor efficacy of TP-PEG-LPs

Authors

  • Xin-jun Cai ZheJiang Chinese Medicine and Western Medicine Integrated Hospital, Department of pharmacy
  • Zeng Wang Zhejiang cancer hospital, Hangzhou, Department of pharmacy
  • Ying-ying Xu ZheJiang Chinese Medicine and Western Medicine Integrated Hospital, Department of pharmacy
  • Lihong Ye ZheJiang Chinese Medicine and Western Medicine Integrated Hospital, Department of Traditional Chinese Medicine
  • Jia-wei Cao ZheJiang Chinese Medicine and Western Medicine Integrated Hospital, Department of pharmacy
  • Jian-jun Ni ZheJiang Chinese Medicine and Western Medicine Integrated Hospital, Department of pharmacy https://orcid.org/0000-0001-5411-7050
  • Ting-ting Wu ZheJiang Chinese Medicine and Western Medicine Integrated Hospital, Department of pharmacy

DOI:

https://doi.org/10.1590/s2175-979020190002181035

Keywords:

Traditional Chinese medicine, Ruanjian Sanjie Decoction, Tumor matrix, Anti-tumor efficacy, Nano-formulations

Abstract

The Ruanjian Sanjie Decoction (RSD) is a traditional Chinese medicine (TCM) formulation consisting of Spica Prunellae, Pseudobulbus Cremastrae Seu Pleiones, Concha Ostreae and Semen Coicis, and widely used as an adjuvant in anti-cancer therapy. The aim of this study was to determine the effects of RSD on the extracellular matrix (ECM) of tumors, and on the efficacy of anti-cancer nano-formulations in a tumor-bearing mouse model. The mice were treated with triptolide encapsulated in PEG-modified liposomes (TP-PEG-LPs), either alone or in combination with RSD. The combination treatment significantly retarded tumor growth relative to the untreated controls, indicating the potent adjuvant effect of RSD in targeted anti-cancer therapy. In addition, RSD also reduced the amount of total collagen and collagen I and increased that of collagen III in the tumor ECM, along with decreasing the expression of the pro-angiogenic VEGF. Finally, even high doses of RSD did not significantly affect the liver and kidney function or body weight, indicating low toxicity.

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Published

2019-12-09

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How to Cite

The traditional Chinese medicine formulation Ruanjian Sanjie Decoction regulates the tumor matrix and improves the anti-tumor efficacy of TP-PEG-LPs. (2019). Brazilian Journal of Pharmaceutical Sciences, 55, e18035. https://doi.org/10.1590/s2175-979020190002181035