Ethanol extract of Cissampelos sympodialis ameliorates lung tissue damage in streptozotocin-induced diabetic rats

Authors

  • Tessio David de Medeiros Federal University of Rio Grande do Norte, Biosciences Center, Departament of Morphology
  • Annyelly Tavares Pereira Federal University of Rio Grande do Norte, Department of Clinical and Toxicological Analysis
  • Flavio Santos da Silva Federal Rural University of Semiarid Region, Departament of Health Sciences
  • Raul Hernandes Bortolin Federal University of Rio Grande do Norte, Department of Clinical and Toxicological Analysis https://orcid.org/0000-0003-3424-3281
  • Karinna Veríssimo Meira Taveira Federal University of Rio Grande do Norte, Biosciences Center, Departament of Morphology
  • Bento João da Graça Azevedo Abreu Federal University of Rio Grande do Norte, Biosciences Center, Departament of Morphology
  • Adriana Augusto de Rezende Federal University of Rio Grande do Norte, Department of Clinical and Toxicological Analysis
  • Naisandra Bezerra da Silva Farias Federal University of Rio Grande do Norte, Biosciences Center, Departament of Morphology
  • José Maria Barbosa Filho University of Paraíba, Laboratoty of Pharmaceutics Tecnology-Federal
  • Karina Carla de Paula Medeiros Federal University of Rio Grande do Norte, Biosciences Center, Departament of Morphology

DOI:

https://doi.org/10.1590/s2175-97902019000417374

Keywords:

Cissampelos sympodialis, Diabetes, Lung, Pancreatic islets, Lipid profile

Abstract

Diabetes Mellitus (DM) is a metabolic syndrome characterized by hyperglycemia. Chronic complications affect a number of organs, including the lungs. Cissampelos sympodialis Eichl (Menispermaceae) is a plant used to treat respiratory diseases. The aim of this study was to evaluate the effect of Cissampelos sympodialis extract (CSE) in lungs of diabetic rats. We used 30 Wistar rats divided into three groups: control group (CG), diabetic group (DG) and diabetic Cissampelos sympodialis treatment group (DTG). Diabetes was induced by streptozotocin (40 mg/kg i.v.). The CSE (400 mg/kg, po) was administered daily, during four weeks, beginning one week after the onset of DM. The treatment with CSE was not able to reduce blood glucose levels after streptozotocin injection. However, it was able to decrease cholesterol and triglycerides and prevent damage on pancreatic islets morphology. Additionally, morphological alterations such as alveolar septa loss, inflammatory infiltrate and fibrosis were seen in lung tissue of rats with DM, and treatment with CSE apparently reversed these histopathological findings. Thus, CSE treatment reduced the lipid profile and restored the lung architecture of diabetic animals by a mechanism independent of glycemia and which might be associated with the reduction of the damage on the pancreatic islets.

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Published

2020-12-09

How to Cite

Medeiros, T. D. de ., Pereira, A. T. ., Silva, F. S. da ., Bortolin, R. H. ., Taveira, K. V. M. ., Abreu, B. J. da G. A. ., Rezende, A. A. de ., Farias, N. B. da S. ., Barbosa Filho, J. M. ., & Medeiros, K. C. de P. . (2020). Ethanol extract of Cissampelos sympodialis ameliorates lung tissue damage in streptozotocin-induced diabetic rats. Brazilian Journal of Pharmaceutical Sciences, 56, e17374. https://doi.org/10.1590/s2175-97902019000417374

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