Synthesis of novel papulacandin D analogs and evaluation of their antifungal potential

Authors

  • Ana Carolina Oliveira Bretas Universidade Federal de Minas Gerais, Faculdade de Farmácia, Departamento de Produtos Farmacêuticos
  • Thiago Belarmino de Souza Universidade Federal de Minas Gerais, Faculdade de Farmácia, Departamento de Produtos Farmacêuticos
  • Beatriz Borelli Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia https://orcid.org/0000-0002-9966-1321
  • Suzana Johan Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia
  • Ricardo José Alves Universidade Federal de Minas Gerais, Faculdade de Farmácia, Departamento de Produtos Farmacêuticos

DOI:

https://doi.org/10.1590/s2175-97902019000417652

Keywords:

β-(1,3)-D-glucan synthase, Antifungal activity, Papulacandin D, Molecular simplification

Abstract

Systemic fungal infections are a growing problem in contemporary medicine and few drugs are licensed for therapy of invasive fungal infections. Differences between fungi and humans, like the presence of a cell wall in fungal cells, can be explored for designing new drugs. (1,3)-β-D-glucan synthase, an enzyme that catalyzes the synthesis of (1,3)-β-D-glucan, a structural and essential component of the fungal cell wall, is absent in mammals and this makes it an excellent target for the development of new antifungal agents. Papulacandins are a family of natural antifungal agents targeting (1,3)-β-D-glucan synthase. In this study we describe the synthesis and biological evaluation of two new Papulacandin analogs as potential (1,3)-β-D-glucan synthase inhibitors.

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Published

2020-12-09

How to Cite

Bretas, A. C. O. ., Souza, T. B. de ., Borelli, B. ., Johan, S. ., & Alves, R. J. . (2020). Synthesis of novel papulacandin D analogs and evaluation of their antifungal potential . Brazilian Journal of Pharmaceutical Sciences, 56, e17652. https://doi.org/10.1590/s2175-97902019000417652

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