Efficacy of secnidazole-diminazene aceturate combination therapy in the late treatment of Trypanosoma brucei brucei infection in dogs

Authors

  • Ifeanyi Gabriel Eke University of Nigeria Nsukka, Enugu State Nigeria, Faculty of Veterinary Medicine, Department of Veterinary Physiology and Pharmacology https://orcid.org/0000-0002-2184-9041
  • Ikenna Onyema Ezeh University of Nigeria Nsukka, Faculty of Veterinary Medicine, Department of Veterinary Parasitology and Entomology
  • Terry Adaeze Ezeudu University of Nigeria Nsukka, Faculty of Veterinary Medicine, Department of Veterinary Parasitology and Entomology
  • Ukamaka Uchenna Eze University of Nigeria Nsukka, Faculty of Veterinary Medicine, Department of Veterinary Medicine
  • Aruh Ottah Anaga University of Nigeria Nsukka, Faculty of Veterinary Medicine, Department of Veterinary Physiology and Pharmacology
  • Patrick Azubuike Onyeyili Federal University of Agriculture Makurdi, Faculty of Veterinary Medicine, Department of Veterinary Physiology and Pharmacology

DOI:

https://doi.org/10.1590/s2175-97902019000318042

Keywords:

Secnidazole, Diminazene aceturate, Combination therapy, Trypanosomosis, Dogs, Relapse

Abstract

This study evaluated the efficacy of combination therapy of secnidazole-diminazene aceturate (SEC‑DA) in late treatment of dogs experimentally infected with relapsing strain of Trypanosoma brucei brucei. Fifteen dogs were randomly assigned to 5 groups (A – E) of 3 per group. Group A (uninfected untreated), B (infected untreated), C (infected and treated with DA (3.5 mg/kg) IM stat), D (infected and treated with secnidazole (SEC) (100 mg/kg) orally for 5 days and DA (3.5 mg/kg) IM stat), E (infected and treated with SEC (200 mg/kg) orally for 5 days and DA (3.5 mg/kg) IM stat). Dogs were infected intraperitoneally with 5 x 105 trypanosomes and treatment started 14 days post-infection. Data on parasitaemia, hematology and rectal temperature were recorded. Parasitaemia cleared within 3 days in all the SEC-DA treated dogs and there was no relapse parasitaemia. Parasitaemia did not clear in DA monotherapy dogs. All the SEC-DA treated dogs showed significantly (P < 0.05) higher leucocyte counts, red blood cell count, packed cell volume, hemoglobin concentration and lower rectal temperature than DA monotherapy. It was, therefore, concluded that SEC-DA combination is therapeutically more efficacious than DA monotherapy in the late treatment of T.b. brucei infection in dogs.

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Published

2020-12-09

How to Cite

Eke, I. G. ., Ezeh, I. O. ., Ezeudu, T. A. ., Eze, U. U. ., Anaga, A. O. ., & Onyeyili, P. A. . (2020). Efficacy of secnidazole-diminazene aceturate combination therapy in the late treatment of Trypanosoma brucei brucei infection in dogs. Brazilian Journal of Pharmaceutical Sciences, 56, e18042. https://doi.org/10.1590/s2175-97902019000318042

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