Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius

Authors

  • Priscylla Maria Martins Cardoso Universidade Vila Velha, Pharmaceutical Sciences Program
  • Renata Alves Mazuco Universidade Vila Velha, Pharmaceutical Sciences Program
  • Lucas Soares Dazzi Macedo Universidade Vila Velha, Pharmaceutical Sciences Program
  • Ariele Abreu Venturini Polese Universidade Vila Velha, Pharmaceutical Sciences Program
  • Maria Eduarda de Souza Barroso Universidade Vila Velha, Pharmaceutical Sciences Program
  • Waléria Gramilich Baratella Universidade Vila Velha, Pharmaceutical Sciences Program
  • Tadeu Uggere de Andrade Universidade Vila Velha, Pharmaceutical Sciences Program
  • Dominik Lenz Universidade Vila Velha, Pharmaceutical Sciences Program
  • Thiago de Melo Costa Pereira Universidade Vila Velha, Pharmaceutical Sciences Program
  • Denise Coutinho Endringer Universidade Vila Velha, Pharmaceutical Sciences Program https://orcid.org/0000-0001-9396-2097

DOI:

https://doi.org/10.1590/s2175-97902019000318051

Keywords:

Nephroprotection, Euterpe edulis Martius, Polyphenols, Anthocyanins, Antioxidant activity

Abstract

Contrast-induced nephropathy (NIC) is directly related to increased morbidity and mortality, and its treatment and prevention might be achieved by the administration of antioxidant products. The juçara palmetto (Euterpe edulis Martius) has fruits rich in phenolic compounds, which are known for their antioxidant activity. This work aimed to evaluate the nephroprotective activity of E. edulis pulp in the NIC animal model. The collected fruits were pulped, their contents of polyphenols and anthocyanins were quantified, and their antioxidant activity were evaluated. The nephroprotective effects were determined based on iodine contrast induction and evaluated by biochemical and histological analyses. The results showed that E. edulis pulp was rich in polyphenols (811 ± 16.7 mg EAG/g) and anthocyanins (181.25 mg/100 g) and had very strong antioxidant activity, as demonstrated by the DPPH (2,2-diphenyl-1- picryl-hydrazyl) method, which revealed an antioxidant activity index (AAI) of 3.4, and the 2,29-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method, which revealed an IC50 of 0.59 ± 0.03 mg/mL. In the in vivo experiments, E. edulis pulp tended to provide renal protection and reduce renal dysfunction and tubular morphological lesions in mice after the induction of NIC, and these effects were obtained through the antioxidant activities of the polyphenols in the pulp.

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Published

2020-12-09

How to Cite

Cardoso, P. M. M. ., Mazuco, R. A. ., Macedo, L. S. D. ., Polese, A. A. V. ., Barroso, M. E. de S. ., Baratella, W. G. ., Andrade, T. U. de ., Lenz, D. ., Pereira, T. de M. C. ., & Endringer, D. C. . (2020). Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius. Brazilian Journal of Pharmaceutical Sciences, 56, e18051. https://doi.org/10.1590/s2175-97902019000318051

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