Microwave-assisted synthesis and pharmacological screening of some triazolothiadiazole derivatives

Authors

  • Ozge Gorgu Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry
  • Engin Yıldırım Osmangazi University, Faculty of Medicine, Department of Pharmacology
  • Yesim Ozkan Gazi University, Faculty of Pharmacy, Department of Biochemistry
  • Bilge Cakır Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry
  • Kevser Erol Osmangazi University, Faculty of Medicine, Department of Pharmacology
  • Tijen Onkol Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry https://orcid.org/0000-0003-3973-5728

DOI:

https://doi.org/10.1590/s2175-97902019000318111

Keywords:

2(3H)-Benzoxazolone, Triazolothiadiazole, Antinociceptive activity, Microwave-assisted synthesis

Abstract

In this study, twenty-two new [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (5a-n, 6a-h) were synthesized under microwave irradiation (MWI). The chemical structures of the compounds were elucidated by their IR, 1 H-NMR, LC-MS, and elemental analysis. The compounds were tested for antinociceptive activity by using the tail clip, tail flick, hot plate, and writhing methods in mice. The varying levels of antinociceptive activity of the compounds were compared with those of aspirin. Among these compounds, compound 5g and 5j were found to be significantly more active than the other compounds and the standard in the tests. Also, inhibitory effects of the test compounds on COX-1 and COX-2 activities were investigated. DuP-697 for COX-2 and SC-560 for COX-1 were used as reference standards.

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Published

2020-12-09

How to Cite

Gorgu, O. ., Yıldırım, E. ., Ozkan, Y. ., Cakır, B. ., Erol, K. ., & Onkol, T. . (2020). Microwave-assisted synthesis and pharmacological screening of some triazolothiadiazole derivatives. Brazilian Journal of Pharmaceutical Sciences, 56, e18111. https://doi.org/10.1590/s2175-97902019000318111

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