A conglomeration of preclinical models related to myocardial infarction

Authors

  • Farogh Ahsan Integral University, Faculty of Pharmacy
  • Tarique Mahmood Integral University, Faculty of Pharmacy https://orcid.org/0000-0002-4006-2594
  • Shazia Usmani Integral University, Faculty of Pharmacy
  • Paramdeep Bagga Integral University, Faculty of Pharmacy
  • Arshiya Shamim Integral University, Faculty of Pharmacy
  • Reshu Tiwari Integral University, Faculty of Pharmacy
  • Neeraj Verma Hygia Institute of Pharmaceutical Education and Research, Department of Pharmacology
  • Mohammed Haris Siddiqui Integral University, Department of Bioengineering

DOI:

https://doi.org/10.1590/s2175-97902019000418365

Keywords:

Myocardial infarction, Animal model, Isoproterenol, Chemical induced, Ischeamia

Abstract

Cardiovascular diseases are the main source of death and morbidity in developed and developing nations. Animal models are required to propel our understanding of the pathogenesis, increase our knowledge, disease progress, and mechanism behind cardiovascular disorder, providing new approaches focused to improve the diagnostic and the treatment of these pathological conditions and additionally to test various therapeutic ways to deal with tissue regeneration and re-establish heart working following damage. A perfect model framework ought to be reasonable, effectively controlled, reproducible, and physiologically illustrative of human disease, show cardinal signs and pathology that resembles after the human ailment and ethically stable. The decision of selection of animal model should be considered precisely since it influences exploratory results and whether results of the research can be sensibly matched with the human. In this way, no specific technique splendidly reproduces the human disease, and relying upon the model, extra cost burden, resources, infrastructure and the necessity for technical hands, should also be kept under consideration. Here we have discussed and compiled various methods of inducing myocardial infarction in animals, basically by surgery, chemicals and through genetic modification, this may benefit the researchers in getting a complied data regarding various methods through which they can induce myocardial infarction in animals.

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Published

2020-12-09

How to Cite

Ahsan, F. ., Mahmood, T. ., Usmani, S. ., Bagga, P. ., Shamim, A. ., Tiwari, R. ., Verma, N. ., & Siddiqui, M. H. . (2020). A conglomeration of preclinical models related to myocardial infarction. Brazilian Journal of Pharmaceutical Sciences, 56, e18365. https://doi.org/10.1590/s2175-97902019000418365

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