PLGA-corosolic acid implants for potential application in ocular neovascularization diseases

Authors

  • Cibele Rodrigues Toledo Federal University of Minas Gerais, Faculty of Pharmacy, Department of Pharmaceutical Products
  • Vinícius Viana Pereira Federal University of Minas Gerais, Faculty of Pharmacy, Department of Pharmaceutical Products https://orcid.org/0000-0002-5928-3880
  • Gracielle Ferreira Andrade Center of Development of the Nuclear Technology (CDTN)
  • Armando Silva-Cunha Federal University of Minas Gerais, Faculty of Pharmacy, Department of Pharmaceutical Products

DOI:

https://doi.org/10.1590/s2175-97902019000418484

Keywords:

Corosolic acid, PLGA, Antiangiogenic activity, Implant

Abstract

Angiogenesis is the formation of new blood vessels from preexisting vasculature. Uncontrolled angiogenesis is associated with progression of several ocular pathologies, such as diabetic retinopathy and macular degeneration. Thus, the inhibition of this process consists in an interesting therapeutic target. Corosolic acid (CA) is a natural derivative of ursolic acid, found in many medicinal herbs and exhibits numerous biological properties, including the antiangiogenic activity. The present study reports the production of CA-loaded poly d,l-lactidecoglycolide acid (PLGA) devices by melt technique. HPLC-UV method was developed and validated to evaluate the uniformity and the release profile of the developed systems. The devices were also characterized by Fourier transform infrared spectroscopy, thermal analysis, and scanning electron morphology. It was studied the antiangiogenic activity of the CA-polymer system, using an in vivo model, the chorioallantoic membrane assay (CAM). CA was dispersed uniformly in the polymer matrix and no chemical interaction between the components of the formulation was verified. The implants presented a sustained release of the drug, which was confirmed by the morphological study and demonstrated an antiangiogenic activity. Therefore, the developed delivery system is a promising therapeutic tool for the treatment of ocular diseases associated with neovascularization or others related to the angiogenic process.

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Published

2020-12-09

How to Cite

Toledo, C. R. ., Pereira, V. V. ., Andrade, G. F. ., & Silva-Cunha, A. . (2020). PLGA-corosolic acid implants for potential application in ocular neovascularization diseases. Brazilian Journal of Pharmaceutical Sciences, 56, e18484. https://doi.org/10.1590/s2175-97902019000418484

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